PR-SET7 在食管癌中表达及其临床意义

PR-SET7 is expressed in human esophageal carcinoma and its clinical significance

摘要:

目的 探讨赖氨酸甲基转移酶PR-SET7 在食管癌组织中的表达及其与临床特征的相关性。方法 应用免疫组织化学法检测武警江苏省总队医院2010 年6 月-2011 年2 月32 例食管癌患者食管癌组织和癌旁组织中PR-SET7 的表达，并探讨PR-SET7 的表达量与患者性别、年龄、细胞分化程度、TNM 分期及淋巴结转移等临床特征的相关性。结果 32 例食管癌组织中均检测到PR-SET7 的表达，癌组织中PRSET7的表达强于癌旁组织，高表达率为81.25%，癌旁组织中以弱表达为主，高表达率为15.62％（P <0.05）。PR-SET7 主要表达在细胞核，食管癌中的表达与肿瘤细胞分化程度、TNM 分期及淋巴结转移相关（P <0.05），与患者的性别、年龄无相关（P >0.05）。结论 食管癌发生与发展过程中PR-SET7 异常表达，其表达水平可能与肿瘤的进展、转移及预后密切相关。

Abstract:

Objectgive To investigate the lysine methyltransferase (PR-SET7) expression in human esophageal cancer tissues and its correlation with clinical features. Methods The immunohistochemistry was used to detect the PR-SET7 expressions in esophageal cancer tissues and adjacent normal tissues of 32 cases at Jiangsu Armed Police General Hospital from June 2010 to February 2011. And the correlations of PR-SET7 expression with patients’ gender, age, degree of carcinoma tissue differentiation, TNM stage and lymph node metastasis were explored. Results Immunohistochemical results showed that PR-SET7 expression was found in all 32 cases of esophageal cancer tissues, and the expression of PR-SET7 in the cancerous tissues was significantly stronger than that of the adjacent tissues. The high-expression rate was 81.25% in theesophageal cancer tissues, the adjacent tissues chiefly had weak expression of PR-SET7 with the high-expression rate of 15.62% (P < 0.05). PR-SET7 mainly expressed in the nuclei of tumor cells. PR-SET7 protein level in the patients with esophageal carcinoma was not correlated with age or sex (P > 0.05), but correlated with tumor cell differentiation, TNM stage and lymph node metastasis (P < 0.05). Conclusions Abnormal expression of PR-SET7 could be found in the process of oncogenesis and progression of esophageal cancer, its expression level is closely associated with tumor pregression, metastasis and prognosis.