Abstract:To explore the epidemiological characteristics of infection Mycoplasma pneumoniae in children with respiratory infections in a hospital during the past 5 years. Methods A total of 378 cases of children with respiratory infections between January 2011 and December 2015 were selected in our hospital. Mycoplasma pneumoniae infection was compared in children with different age, sex and type of disease, and at different seasons and places of residence. Results The rates of Mycoplasma pneumoniae infection in the children younger than 1 year, children of 1-3 years, 3-5 years, and more than 5 years were 10.96%, 19.15%, 30.61% and 40.71% respectively. The infection rates of male and female children were 21.59% and 35.10% respectively. The infection rates in spring, summer, autumn and winter were 18.63%, 16.48% and 33.68% and 40.00% respectively. The infection rates of children in urban and rural areas were 31.12% and 22.53% respectively. The infection rates of children with lobar pneumonia, interstitial pneumonia, bronchial asthma, bronchopneumonia, bronchitis, upper respiratory tract infection and bronchiolitis were 66.67%, 50.00%,46.51%, 26.67%, 25.00%, 20.59% and 10.17% respectively. Conclusions The risk of Mycoplasma pneumoniae infection in children with respiratory tract infections is high. Children with older age and lobar pneumonia and female children are more susceptible to Mycoplasma pneumoniae infection. Autumn and winter are the high-occurrence seasons.