事件相关电位检测与认知功能评价的相关性分析

Correlation analysis of detection of event related potential and evaluation of cognitive function

摘要:

对认知功能评估量表（MoCA）与事件相关电位（ERPs）成分进行相关性分析，寻找认知功能评价客观指标。方法采用MoCA 评价认知功能，三刺激oddball 范式进行ERPs 分析，分析MoCA 得分与ERPs成分波幅与潜伏期的关系。结果对68 例中老年人被试的相关分析显示，失匹配负波潜伏期及波幅与MoCA得分无相关性（p >0.05），新异P300（P3a）潜伏期与MoCA 得分呈负相关（r =-0.427，p =0.000），P3a 波幅与MoCA得分呈负相关（r =-0.314，p=0.009）。结论可以通过检测ERPs的P3a成分来反映总体认知功能，作为认知功能检查的客观指标。

Abstract:

To investigate the correlation between the event related potentials (ERPs) and evaluation of Montreal Cognitive Assessment (MoCA). Methods The cognitive function of aged people was evaluated by MoCA. Then ERPs data revelant to audio oddball paradigm in participants were recorded and analyzed. The regression analysis was applied to investigate the relationships of the MoCA score with latency and amplitudes of ERPs components. Results The MMN and P3a components of ERPs were recorded in all the participants. No correlation was found between MMN and the score of MoCA (p > 0.05). There was a negative correlation between P3a latency and MoCA (p = 0.000). A negative correlation between P3a amplitude and MoCA was found (p = 0.009). Conclusions The P3a component of ERPs can be used as an objective index to examine the cognitive function of aged people.