类赖氨酰氧化酶1在翼状胬肉中的表达

Expression of lysyloxidase like 1 in pterygium

摘要:

目的通过检测正常结膜组织和翼状胬肉中类赖氨酸氧化酶1（LOXL-1）的表达，探讨LOXL-1 在翼状胬肉发展过程中的影响及意义。方法采用免疫组织化学检查正常结膜组织（19 例）和翼状胬肉组织（25例）中LOXL-1 的表达情况，测定两组免疫组织化学结果的光密度值。结果正常结膜组织与翼状胬肉中LOXL-1 的光密度值比较，差异有统计学意义（P <0.05），正常结膜组织偏低。结论翼状胬肉组织中LOXL-1的表达较正常结膜组织高，LOXL-1 在翼状胬肉发展中起到了促进的作用。

Abstract:

Objective To compare the expression of lysyloxidase like 1 (LOXL-1) in normal conjunctiva tissues and pterygium, and explore the influence and significance of LOXL-1 in the course of pterygium development. Methods Using immunohistochemistry, LOXL-1 expression in normal conjunctiva tissues (19 cases) and pterygium(25 cases) was examined, optical density value was detected. Then test was carried out. Results The optical density value in the normal conjunctiva tissues was lower than that in the pterygium (P < 0.05). Conclusions The expression of LOXL-1 in pterygium is higher than that in normal conjunctiva tissues. LOXL-1 plays an important role in promoting the development of pterygium.