MicroRNA-31 在上皮性卵巢癌中的表达及其与预后的关系

Relationship between miR-31 expression and prognosis of patients with epithelial ovarian cancer

摘要:

目的 本研究旨在探讨microRNA-31（miR-31）在上皮性卵巢癌（EOC）中的表达水平与临床病理学因素以及预后的关系。方法 采用实时荧光定量聚合酶链反应（qRT-PCR）检测150 例EOC 患者组织中miR-31 的表达水平，将miR-31 表达情况与随访结果和临床资料相结合进行统计学分析。结果 在EOC 组织中miR-31 的表达较癌旁正常卵巢组织降低（P <0.05）。miR-31 的低表达与较差的组织学分级、较多的淋巴结转移、更广泛的腹膜转移和更晚期的病理分期有关（P <0.05），而与其他临床病理学因素无关（P >0.05）。此外，miR-31 的表达是患者总生存的独立预测因子。结论 miR-31 可能是EOC 一个新的诊断和预后标志物。

Abstract:

Objective To investigate the expression of miR-31 in epithelial ovarian cancer (EOC), and analyze the relationship of its expression with clinicopathological features and prognosis. Methods qRT-PCR was performed to detect miR-31 expression in the EOC tissues. The correlations of miR-31 expression with follow-up results and clinicopathological factors of the EOC patients were analyzed. Results The expression of miR-31 in the EOC tissues was reduced significantly compared with the adjacent normal tissues (P < 0.05). Low expression of miR-31 was correlated with higher histological grade, lymph node metastasis, peritoneal metastasis, and higher FIGO stage(P < 0.05), but was irrelevant with other clinical pathological factors (P > 0.05). In addition, the expression of miR-31 was an independent prognostic factor for overall survival of the patients. Conclusions It is possible that miR-31 serves as a diagnostic and prognostic marker in clinical practice.