生殖道支原体感染与IVF 临床结局的相关性分析

Correlation between genital tract Mycoplasma infection and clinical outcome of IVF

摘要:

目的 探讨接受体外受精- 胚胎移植（IVF-ET）治疗的患者中生殖道支原体检测阳性对IVF 临床结局的影响及术前进行支原体检查的临床意义。方法 回顾性分析2012 年5 月-2015 年4 月唐山市妇幼保健院生殖中心接受IVF-ET 治疗的不孕患者1 237 例，按分泌物支原体培养结果分为双方阴性（A 组）、仅女方阳性（B 组）和仅男方阳性（C 组）3 组。分析统计3 组的正常受精率、异常受精率、卵裂率、D3 优质胚胎率、临床妊娠率、种植率、流产率、早产率、低体重儿出生率等数据；将移植后剩余胚胎进行囊胚培养，统计分析囊胚形成率、优质囊胚率及冷冻率。结果 阳性组与阴性组相比各组数据差异均无统计学意义（P >0.05）。结论 不管女方还是男方支原体培养结果阳性对IVF 的最终临床结局无明显影响，在患者无主观症状的情况下，支原体检查不是必须的。

Abstract:

Objective To investigate the effect of genital tract Mycoplasma infection on the clinical outcome of patients during in vitro fertilization and embryo transfer (IVF-ET) cycles and the clinical significance of preoperative test. Methods A retrospective analysis was carried out on 1,237 infertile patients receiving IVF-ET treatment at the Reproductive Center of our hospital from May 2012 to April 2015. The patients were divided into negative group(group A), female positive group (group B) and male positive group (group C) according to the results of culture of Mycoplasma in secretions. The normal fertilization rate, abnormal fertilization rate, cleavage rate, D3 high-quality embryo rate, clinical pregnancy rate, implantation rate, abortion rate, preterm delivery rate and low-weight birth rate were compared among the three groups. After the transfer the surplus embryos were cultured to blastocysts.The blastocyst development rate, high-quality blastocyst rate and freezing rate were analyzed. Results There was no statistical difference in each index between the positive groups and the negative group (P > 0.05). Conclusions Whether in woman or man, Mycoplasma-positive result has no significant effect on clinical outcomes of IVF. In the absence of subjective symptoms, Mycoplasma test is not necessary.