Abstract:To observe the advantages of dual-wavelength laser over Minocycline Hydrochloride in the treatment of periodontal endodontic lesions. Methods In this study 48 teeth were collected from 43 patients with periodontal endodontic lesions and randomly divided into 2 groups. In the experiment group, Nd:YAG was used to disinfect the root canals, and Er:YAG laser irradiation was utilized to treat periodontal pockets. In the control group, iodophor was applied to root canal preparation, and Minocycline Hydrochloride was used to treat periodontal pockets. Using Visual Analog Scale (VAS) the difference in pain was observed between the two groups 1 day after treatment. Periodontal pocket depth (PD), periodontal attachment level and tooth mobility were compared between the two groups after 1, 2 and 3 weeks, 3 and 6 months; then the efficacy was evaluated. Results The pain relief 1 day after treatment was significantly different between the two groups. There were significant differences in PD, periodontal attachment level and resting state VAS score between the two groups. The treatment of PD, periodontal attachment level and loosening of teeth was more efficient in the experimental group compared to the control group. Conclusions Combination of Er:YAG laser and Nd:YAG laser is better than Minocycline Hydrochloride for the treatment of periodontal endodontic lesions.