高压氧对急性缺血性脑卒中患者脑源性神经营养因子的影响

Effect of hyperbaric oxygen on BDNF in patients with acute ischemic stroke

摘要:

目的 探讨高压氧对急性缺血性脑卒中患者脑源性神经营养因子（BDNF）的影响。方法 选择2014 年2 月-2016 年12 月在该院神经内科住院的130 例急性缺血性脑卒中患者作为研究对象，根据信封随机抽签原则分为观察组与对照组，每组65 例。给予对照组常规治疗，基于观察组的治疗，给予对照组高压氧治疗，10 d 为1 个疗程，治疗观察3 个疗程，记录两组预后情况。结果 观察组与对照组疗效比较，采用χ2检验，差异有统计学意义（χ2=4.298，P =0.038），观察组疗效高于对照组。两组治疗后ESS 评分与治疗前比较，采用配对t 检验，差异有统计学意义（t =19.996 和10.552，均P =0.000），两组治疗后ESS 评分高于治疗前；两组治疗后ESS 评分比较，采用成组t 检验，差异有统计学意义（t =11.095，P =0.000），观察组治疗后ESS 评分高于对照组。两组治疗后血清BDNF 含量与治疗前比较，采用配对t 检验，差异有统计学意义（t =7.787 和3.198，P =0.000 和0.002），两组治疗后血清BDNF 含量高于治疗前；两组治疗后血清BDNF 含量比较，采用成组t 检验，差异有统计学意义（t =5.827，P =0.000），观察组治疗后血清BDNF 含量高于对照组。观察组与对照组日常生活能力比较，采用χ2 检验，差异有统计学意义（χ2=5.632，P =0.018），观察组日常生活能力高于对照组。结论 高压氧在急性缺血性脑卒中患者治疗中的应用能促进血清BDNF 的分泌，从而提高患者的神经功能与日常生活能力，改善预后，有很好的应用价值。

Abstract:

Objective To investigate the effect of hyperbaric oxygen on brain-derived neurotrophic factor(BDNF) in patients with acute ischemic stroke. Methods One hundred and thirty patients with acute ischemic stroke hospitalized in the Department of Neurology of our hospital from February 2014 to December 2016 were selected as the objects of study. According to the envelope principles, all the patients were equally divided into the observation group and control group with 65 patients in each group. The control group was given conventional treatment; the observation group received hyperbaric oxygen therapy based on the conventional treatment, 10 days for a course of treatment. After treatment for 3 courses, the outcome in the two groups was recorded. Results The efficacy of the observation group was statistically higher than that of the control group (χ2 = 4.298, P = 0.038) . The ESS scores after treatment in the two groups were significantly higher than those before treatment (t = 19.996 and 10.552, P = 0.000), the ESS score after treatment in the observation group was statistically higher than that in the control group (t = 11.095, P = 0.000). The serum BDNF levels after treatment in the two groups were statistically higher than those before treatment (t = 7.787 and 3.198, P = 0.000 and 0.002); comparison of serum BDNF levels between the two groups, using independent samples t-test, the difference was statistically , the serum BDNF level after treatment in the observation group was significantly higher than that in the control group (t = 5.827,P = 0.000). The daily living ability of the observation group was higher than that of the control group (χ2 = 5.632,P = 0.018). Conclusions Hyperbaric oxygen in the treatment of patients with acute ischemic stroke can promote the secretion of serum BDNF, so as to improve the patient’s neurological function and daily life ability and improve the prognosis; therefore, it has good application value.