青年原发高尿酸血症氧化应激与炎症的关系研究

Relationship between oxidative stress and inflammatory response in young patients with primary hyperuricemia

摘要:

目的分析青年原发高尿酸血症氧化应激与炎症的关系。方法选取青年原发高尿酸血症患者64例为高尿酸（HUA）组，健康体检者60 例为对照组，检测血清丙二醛（MDA）、超氧化物歧化酶（SOD）、白介素6（IL-6）、肿瘤坏死因子α（TNF-α）水平。结果HUA组MDA、IL-6、TNF-α高于对照组，SOD 低于对照组（p <0.05）；血清尿酸水平与MDA、IL-6、TNF-α呈正相关，与SOD 呈负相关（p <0.05）；MDA与IL-6、TNF-α呈正相关（p <0.05），SOD 与IL-6、TNF-α呈负相关（p <0.05）；尿酸、MDA 及SOD 是IL-6、TNF-α的影响因素（p<0.05）。结论青年原发高尿酸血症患者体内呈氧化应激及微炎症状态，而患者体内炎症应答可能与高尿酸引起的氧化应激反应有关。

Abstract:

Objective To analyze the relationships between oxidative stress indexes and inflammatory indexes in young patients with primary hyperuricemia. Methods Asymptomatic young patients (64 cases) with primary hyperuricemia found during physical examination were selected as hyperuricemic group, 60 healthy persons were selected as control group. The levels of serum MDA, IL-6 and TNF-α and SOD activity were detected, and statistic analyses were carrid out. Results The levels of MDA, IL -6 and TNF -α in the hyperuricemic group were significantly higher than those in the control group (p < 0.05), and the SOD activity was significantly lower than that in the control group (p < 0.05). The level of serum uric acid was positively correlated with MDA, IL-6 and TNF-α(p < 0.05), but negatively correlated with SOD (p < 0.05). The serum MDA level was positively correlated with IL-6 and TNF-α(p < 0.05). The SOD activity was negatively correlated with IL-6 and TNF-α( p< 0.05). Serum uric acid, MDA and SOD were the influencing factors of IL-6 and TNF-α(p < 0.05). Conclusions There are oxidative stress and micro-inflammatory state in young patients with hyperuricemia, and the inflammatory response may be related to the oxidative stress response induced by hyperuricemia.