OPN 与AL 患者临床特征及预后的关系

Correlations of osteopontin with clinical characteristics and prognosis of primary systemic amyloidosis

摘要:

目的 探讨骨桥蛋白（OPN）与原发性系统性淀粉样变（AL）临床特征及预后的关系。方法选择2005 年3 月-2015 年3 月于佛山市中医院检验医学中心就诊的原发性系统性淀粉样变患者60 例作为AL 组，分析不同临床特征之间的OPN 水平。选择同期在该院进行健康查体者60 例作为对照组，检测两组研究对象OPN 水平和肌钙蛋白t（cTnT）水平，分析OPN 水平与cTnT 水平的相关性。并检测AL 组经自体干细胞移植术治疗后不同预后患者OPN 和cTnT 水平。结果 OPN 水平在AL 患者中不同肾小球滤过率、受累器官数、纽约心脏病协会心功能分级、二尖瓣环收缩速度、射血分数、心肌质量指数及左心房直径之间比较，差异有统计学意义（P <0.05）。AL 组OPN 和cTnT 的水平均高于对照组的水平（P <0.05），且OPN 水平与cTnT 的水平呈正相关（P <0.05）。结论 OPN 水平与AL 临床特征及预后有关，在AL 的诊断及预后评估中具有重要的临床价值。

Abstract:

Objective To investigate the correlations of serum osteopontin (OPN) level with clinical characteristics and prognosis of primary systemic amyloidosis (AL). Methods In this study, 60 patients with AL (AL group) treated in our hospital between March 2005 and March 2015 were enrolled. The OPN levels in the AL patients with different clinical features were analyzed. Meanwhile, 60 healthy subjects having health examination during the same period were selected as the control group. The levels of OPN and troponin t (cTnT) in the two groups were compared. Also, the correlation analysis between OPN level and cTnT level was conducted. After autologous stem cell transplantation, the levels of OPN and cTnT in the AL patients with different prognosis were detected. Results The OPN levels were significantly different in the AL patients with different glomerular filtration rate, number of organs involved, NYHA (New York Heart Association) classification grade of heart function, speed of mitral annular contraction, ejection fraction, cardiac mass index and diameter of left atrium (P < 0.05). The levels of OPN and cTnT in the AL group were higher than those in the control group (P < 0.05). Moreover, the OPN level showed a positive correlation with cTnT level (P < 0.05). Conclusions The level of OPN is related to the clinical characteristics and prognosis of primary systemic amyloidosis, and has important clinical value in the diagnosis and prognostic evaluation of the disease.