血清TGF-β1、CTGF 与增生性糖尿病视网膜病变的关系

Correlations of serum levels of TGF-β1 and CTGF with proliferative diabetic retinopathy

摘要:

目的 探究血清转化生长因子β1（TGF-β1）和结缔组织生长因子（CTGF）的表达与增生性糖尿病视网膜病变（PDR）的临床关系。方法 选取在河南科技大学第一附属医院就诊的2 型糖尿病患者230 例，依据是否合并视网膜病变，将所有患者分为PDR 组和非增生性糖尿病性视网膜病变（NPDR）组，其中PDR 组120 例，NPDR 组110 例，同时选取110 例健康人员作为对照组，收集整理3 组患者的 TGF-β1、CTGF 和其余临床资料，并进行比较。结果 与NPDR 组和对照组相比，PDR 组的血清低密度脂蛋白水平较高（P <0.05）；与NPDR 组相比，PDR 组的病程较长（P <0.05）；PDR 组的血清TGF-β1 和CTGF 表达水平高于NPDR 组和对照组（P <0.05），NPDR 组与对照组的血清TGF-β1、CTGF 表达水平比较，差异无统计学意义（P >0.05）。结论 PDR 患者血清TGF-β1、CTGF 表达水平较高，与PDR 的发病具有一定相关性。

Abstract:

Objective To explore the clinical relationships of serum expressions of transforming growth factor (TGF-β1) and connective tissue growth factor (CTGF) with proliferative diabetic retinopathy (PDR). Methods A total of 230 patients with type 2 diabetes in our hospital from August 2013 to November 2015 were selected, and divided into the PDR group (120 cases) and the NPDR group (110 cases) according to whether they had retinopathy or not, then 110 healthy people were chosen as the control group. Serum TGF-β1 and CTGF and other clinical data of the three groups were collected, sorted and compared. Results Compared to the NPDR group and the control group, the serum level of low-density lipoprotein in the PDR group was significantly higher (P < 0.05).Compared to the NPDR group, the course of disease in the PDR group was significantly higher (P < 0.05). The serum levels of TGF-β1 and CTGF in the PDR group were significantly higher than those in the NPDR group and the control group (P < 0.05), but there were no significant differences between the NPDR group and the control group (P > 0.05). Conclusions Serum levels of TGF-β1 and CTGF are higher in the patients with PDR. And they have certain correlations with the onset and course of PDR.