年轻患者子宫内膜癌组织中ER、PR、P53病理表达情况及其临床意义

Expressions of ER, PR and p53 in young patients with endometrial carcinoma and clinical significance

摘要:

探讨年轻子宫内膜癌患者临床资料及组织中ER、PR、P53 病理表达情况及其临床意义。方法选取郑州大学第二附属医院子宫内膜癌患者，以年龄45 岁为界分为A、B 两组，回顾性分析其临床病理资料。结果与年龄≥45 岁子宫内膜癌患者比，年龄<45 岁内膜癌患者孕次及产次、是否有合并症、组织学分级、肌层浸润深度、PR阳性率及P53 阳性率差异有统计学意义（p <0.05）。ER，PR 表达与年龄呈负相关，P53阳性表达与组织学分级呈正相关（r =0.289，r <0.05），与肌层浸润深度呈负相关（r =-0.345，p >0.05）。结论①年轻子宫内膜癌患者应加强子宫内膜监控及自身健康管理；②年轻患者子宫内膜癌组织中ER、PR表达较高，为其选择激素治疗可行性提供证据支持；③年轻患者子宫内膜癌组织中P53 阳性表达率低，P53 阳性表达与内膜癌组织学分级、肌层浸润深度相关，可作为推断预后的指标。

Abstract:

To retrospectively analyze the clinical data of endometrial cancer in young patients, and study the expressions of ER, PR and p53 in the cancer tissues, in the order to know the clinical significance. Methods A total of 424 cases of endometrial carcinoma were divided into two groups by age of 45 years. Their clinical and pathological data were retrospectively analyzed, and the incidence of endometrial cancer in the young patients and prognostic factors were studied. Results There were significant differences in the gravidity and parity history, the presence of complications or not, the histological grade, the depth of myometrial invasion and the positive rates of PR and p53 between the patients ≥45 years of age and those <45 years of age (p < 0.05). In the endometrial cancer patients <45 years of age, ER and PR expressions were negatively correlated with age; p53 expression was positively correlated with histological grade (r = 0.289,p < 0.05) but negatively correlated with depth of myometrial invasion (r = -0.345,p < 0.05). Conclusions Endometrial cancer monitoring and health management should be strengthened in young patients with endometrial cancer. Higher expressions of ER and PR in young patients with endometrial carcinoma provide evidence for the feasibility of hormone therapy. In young patients with endometrial cancer, p53 expression is low; positive expression of p53 is correlated with histological grade and depth of myometrial invasion, therefore, p53 can be used as an index of prognosis.