血浆NT-proBNP 对心肌梗死发病部位及患者生存的影响

Effect of plasma NT-proBNP on location of myocardial infarction and survival of patients

摘要:

目的 探究血浆N 端B 型脑利钠肽前体（NT-proBNP）对心肌梗死患者发病部位及生存状况的影响。方法 回顾性分析2013 年6 月-2015 年6 月于阜阳市第二人民医院收治的96 例心肌梗死患者的临床资料，并选取同期健康检查的30 例患者作为对照组。分析血浆NT-proBNP 水平与患者梗死部分及生存状况的关系。结果 心肌梗死患者中发病率最高的部位依次为下壁梗死（39.58％），血浆NT-proBNP 水平由低到高分别为下壁梗死、前间壁梗死、前侧壁梗死及前壁梗死，梗死面积由小到大分别为下壁梗死、前间壁梗死、前侧壁梗死及前壁梗死；出院后1、12 个月心肌梗死再发、心力衰竭和死亡患者的血浆NT-proBNP水平高于未发生患者（P <0.05）。结论 前壁梗死的心肌梗死患者血浆NT-proBNP 水平最高，且血浆NTproBNP水平越高，心肌梗死面积越大，生存率越低。

Abstract:

Objective To explore the effect of plasma N-terminal B type brain natriuretic peptide precursor (NT-proBNP) on the location of myocardial infarction and survival condition of the patients. Methods The clinical data of 96 patients with myocardial infarction in our hospital from June 2013 to June 2015 were retrospectively analyzed, and 30 people of health examination at the same period were selected into control group. The correlations of plasma NT-proBNP level with location of myocardial infarction and the patients’ survival condition were analyzed. Results In the patients with myocardial infarction the most frequently occurred lesions were inferior wall infarction (39.58%); the plasma levels of NT-proBNP from low to high were in patients with inferior wall infarction,anteroseptal wall infarction, anterolateral wall infarction, anterior wall infarction; the infarction area increased from inferior wall infarction, anteroseptal wall infarction, anterolateral wall infarction to anterior wall infarction. The plasma NT-proBNP levels in the patients with recurrence of myocardial infarction 1 and 12 months after discharge,heart failure and death were higher than those in the patients without, the differences were statistically significant (P< 0.05). Conclusions The level of plasma NT-proBNP is the highest in the patients with anterior wall infarction; and the higher the level of NT-proBNP, the larger the myocardial infarction area, the lower the survival rate.