年龄、体重指数与女性生育因素对乳腺密度的影响研究

Influence of age, BMI and fertility factors on female breast density

摘要:

目的 探讨年龄、体重指数（BMI）与女性生育因素对乳腺密度的影响。方法 对符合纳入标准且自愿接受全数字乳腺X 射线检查的女性5 006 例，依据第4 版ACR BI-RADS 分类系统对乳腺密度进行分型，分析年龄、BMI 及女性生育因素与乳腺密度间的关系。结果 乳腺密度在不同年龄段之间比较，差异有统计学意义（P <0.05）。BMI、初潮年龄、持续时间、是否绝经、孕次数、母乳喂养时间及活产数在4 个乳腺密度类型间差异均具有统计学意义（P <0.05），而月经周期差异无统计学意义（P >0.05）。对乳腺密度有影响的因素进行Logistic 分析显示，只有年龄、BMI、是否绝经、活产数及母乳喂养时间进入方程，对乳腺密度类型有影响作用。结论 年龄、BMI、是否绝经、活产数及母乳喂养时间对乳腺密度有不同程度影响。

Abstract:

Objective To probe into the relationships between female breast density and age, BMI and fertility factors. Methods By accepting the digital mammography X-ray examination for 5, 006 female cases and according to the ACR BI-TADS standard in the fourth edition, the breast density assessment was quantified. The relationships of breast density with age, BMI and fertility factors were analyzed. Results There were statistical differences in the breast density among different age groups (P < 0.05). There were statistical differences among the four groups with different breast density in BMI, menarche age, menstrual duration, pausimenia, gravidity and parity history, breastfeeding time and number of live births (P < 0.05); but not in menstrual cycle (P > 0.05). Logistic regression analysis showed that age, BMI, pausimenia, number of live births, and breast-feeding time were the influencing factors for breast density. Conclusions Age, BMI, pausimenia, breast-feeding duration and number of live births have effects on breast density.