2015年某县恶性肿瘤病因分析

Analysis of etiology of malignant tumors in Changsha County in 2015

摘要:

目的了解长沙县恶性肿瘤的患病现况，探讨恶性肿瘤发病的危险因素。方法采用整群随机抽样方法，将已被确诊为恶性肿瘤的40 名患者作为病例组，将从正常人群随机抽样的430 名患者作为对照组。对两组患者进行单因素分析，再以多因素非条件Logistic 回归模型筛选主要危险因素。结果恶性肿瘤患病率为522/10 万。单因素分析显示肿瘤遗传史、年龄、体重指数、饮食习惯、文化程度、吸烟、饮酒及活动时间与肿瘤的发生有一定的关联，多因素分析显示年龄、肿瘤遗传史、体重指数、饮食习惯、吸烟及活动时间是恶性肿瘤的危 险因素。结论恶性肿瘤发病与遗传有关，也与饮食习惯、生活方式有关，平衡饮食、改变生活方式可有效预防恶性肿瘤。

Abstract:

Objective To understand the prevalence of malignancies in Changsha County, and to explore the risk factors for occurrence of malignant tumors. Methods Using cluster random sampling method, 40 patients diagnosed with malignant tumors in Changsha County were regarded as case group, and 430 normal people in the same area as control group. SPSS18.0 was used for single factor analysis, and then multivariate logistic regression model was used for screening of major risk factors. Results The prevalence of malignant tumors was 522/105. Univariate analysis showed that age, BMI, education level, family history of cancer, diet of fruits and vegetables, smoking, drinking and activity time had certain relevance to tumorigenesis. Multivariate analysis showed that age, BMI, family history of cancer, diet of fruits and vegetables, smoking and activity time were the risk factors of malignant tumors. Conclusions The incidences of malignant tumors are related to heredity, as well as diet and life style. Balanced diet and healthy life style can effectively prevent malignant tumors.