糖化白蛋白对糖尿病合并急性脑梗死患者同型半胱氨酸水平的影响

Effects of glycated albumin on homocysteine in diabetic patients complicated with acute cerebral infarction

摘要:

摘要：目的  探讨糖化白蛋白（GA）对糖尿病合并急性脑梗死患者血浆同型半胱氨酸（Hcy）水平的影响。方法  选取糖尿病合并急性脑梗死患者236例，分为A、B两组。A组GA<17.0%，93例；B组GA≥17.0%，143例。比较两组基本临床资料及血浆Hcy水平。结果  两组GA和空腹血糖比较，差异有统计学意义（P <0.05），B组GA和空腹血糖水平较A组升高。A组血浆Hcy水平为14.91（11.47，20.24）μmol/L，B组血浆Hcy水平为16.22（12.40，25.13）μmol/L，两组比较，差异有统计学意义（P <0.05），B组血浆Hcy水平较A组升高。血浆Hcy水平与GA、空腹血糖呈正相关，而与总胆固醇呈负相关。GA升高是血浆Hcy水平升高的独立相关因素。结论  高GA水平的糖尿病合并急性脑梗死患者血浆Hcy升高。

Abstract:

Abstract: Objective To investigate the effect of glycated albumin (GA) on homocysteine in diabetic patients complicated with acute cerebral infarction. Methods A total of 236 acute cerebral infarction patients with diabetes were chosen and divided into group A (93 case, GA < 17.0%) and group B (143 cases, GA ≥ 17.0%). Height, weight, blood pressure, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, fasting blood glucose, glycated albumin, and plasma homocysteine were detected and compared. Results The levels of glycated albumin and fasting blood glucose were significantly higher in the group B compared with the group A (P < 0.05). The level of homocysteine was 14.91 (11.47, 20.24) μmol/L in the group A and 16.22 (12.40, 25.13) μmol/L in the group B, there was significant difference (P < 0.05). The level of homocysteine was positively correlated with the levels of GA and fasting blood glucose, but negatively associated with the level of total cholesterol. GA elevation was an independent factor related to increased plasma homocysteine level. Conclusions The plasma level of homocysteine increases in diabetic patients with acute cerebral infarction who have high glycated albumin level.