P53、Her-2 和Ki67 在甲状腺乳头状癌中的表达及其临床意义

Expressions of p53, Her-2 and Ki67 in thyroid papillary carcinoma and their clinical significance

摘要:

目的 探讨P53、Her-2 和Ki67 在甲状腺乳头状癌中的表达及临床意义。方法 采用免疫组织化学法，分别研究128 例甲状腺乳头状癌肿瘤组织，56 例甲状腺腺瘤组织，以及9 例正常甲状腺组织标本中P53、Her-2 和Ki67 的表达。结果 P53、Her-2 和Ki67 在正常甲状腺组织中无阳性表达。甲状腺乳头状癌组织中P53 阳性表达率为85.15%（109/128），高于腺瘤组织的26.78%（15/56）（P <0.05）。甲状腺乳头状癌组织中Her-2 阳性表达率为25.78%（33/128），高于腺瘤组织的12.49%（7/56）（P <0.05）。甲状腺乳头状癌和腺瘤组织中的Ki67 阳性率分别为38.28%（49/128）和23.21%（13/56），差异无统计学意义（P >0.05）。结论 P53、Her-2 对临床评估甲状腺乳头状癌的发生、发展及预后有一定指导意义，Ki67 对鉴别甲状腺乳头状癌无明确临床意义。

Abstract:

Objective To investigate the expressions of p53, Her-2 and Ki67 in thyroid papillary carcinomas (TPC) and their significance. Methods The expressions of p53, Her-2 and Ki67 in 128 cases of TPC, 56 cases of thyroid adenomas and 9 cases of normal thyroid tissues were detected by immunohistochemical technique. Results There was no positive expression of p53, Her-2 or Ki67 in the normal thyroid tissues. The positive expression rate of p53 in the TPC was 85.15% (109/128) which was significantly higher than 26.78% (15/56) of the thyroid adenomas (P < 0.05). The positive expression rate of Her-2 in the TPC was 25.78% (33/128) which was significantly higher than 12.49% (7/56) of the thyroid adenomas (P < 0.05). The positive rates of Ki67 expression in the TPC and the thyroid adenomas were 38.28% (49/128) and 23.21% (13/56) respectively, the statistical analysis showed no significant difference between the two groups (P > 0.05). Conclusions P53 and Her-2 expressions have certain guiding significance for the evaluation of the occurrence, development and prognosis of thyroid papillary carcinoma. Ki67 has no definite clinical significance in differential diagnosis of TPC.