3-DUS和TUI超声技术在胎儿畸形筛查中的应用价值

Application of 3-DUS and TUI ultrasonography to fetal malformation screening

摘要:

探讨表面三维成像技术（3-DUS）与断层超声显像技术（TUI）在筛查胎儿畸形中的应用价值。方法选取1 896 例于该院行三维超声检查的孕妇为研究对象，采用3-DUS 技术与TUI 技术检查胎儿畸形情况。结果胎儿畸形发生率为3.22%，体表畸形发生率为65.57%，体内畸形发生率为34.43%；3-DUS 技术体表畸形阳性检出率为97.50%，体内畸形检出率为19.05%，TUI 技术体表畸形阳性检出率为42.50%，体内畸形检出率为100%；3-DUS 技术诊断胎儿畸形敏感性、特异性分别为70.49%和99.46%，TUI 技术诊断胎儿畸形敏感性、特异性分别为62.30%和99.35%，两者比较，差异无统计学意义（p >0.05），3-DUS 与TUI 技术联合诊断胎儿畸形敏感性、特异性分别为100%和99.89%，其敏感性高于单纯3-DUS 及单纯TUI 诊断（p <0.05），特异性高于单纯3-DUS 及单纯TUI诊断，但差异无统计学意义（p >0.05）。结论3-DUS 技术诊断胎儿体表畸形检出率高，TUI 技术诊断胎儿体内畸形检出率高，两者联合在胎儿畸形筛查中具有较高应用价值。

Abstract:

To investigate the application of 3-DUS and TUI ultrasonography in fetal malformation screening. Methods Totally 1,896 pregnant women in our hospital were selected as the research objects. 3-DUS technique and TUI technique were used to examine fetal malformations. Results The rate of fetal malformations was 3.22%, in which surface malformations accounted for 65.57% and internal malformations accounted for 34.43%. Using 3-DUS the positive detection rate of surface deformities was 97.50%, that of internal malformations was 19.05%. Using TUI the positive detection rate of surface malformations was 42.50%, that of internal malformations was 100%. The sensitivity and specificity of 3-DUS in the diagnosis of fetal malformations were 70.49% and 99.46% respectively, those of TUI in the diagnosis of fetal malformations were 62.30% and 99.35% respectively, there were no significant differences between the two techniques (p > 0.05). The sensitivity and specificity of 3-DUS combined with TUI in the diagnosis of fetal abnormalities were 100.00% and 99.89%, the sensitivity was significantly higher than that of pure 3-DUS diagnosis and pure TUI diagnosis (p < 0.05), the specificity was also higher than that of pure 3-DUS diagnosis and pure TUI diagnosis but without significant differences (p > 0.05). Conclusions 3-DUS technique has a high detection rate of fetal surface malformations, while TUI technique has a high detection rate of fetal internal malformations. The combination of the two techniques has high application value in screening of fetal malformations.