乳腺超声假阴性乳腺癌的临床分析

Clinical analysis of false negative breast cancer by breast ultrasonography

摘要:

回顾性分析乳腺超声假阴性与真阳性之间差异，总结该类病例的临床特点。方法选取2006～2015 年华北理工大学附属医院经病理证实的女性原发性乳腺癌649 例，根据其超声表现，分为假阴性组和真阳性组，对比分析两组患者的发病年龄、绝经与否、病灶部位及大小、病理类型及淋巴结转移情况等因素与乳腺超声在乳腺癌检出中的关系。结果乳腺超声假阴性的比例为6.6%。假阴性组与真阳性组年龄构成比较，青年（≤40 岁）比例高；肿瘤位于乳晕区、内侧象限的比例高；肿瘤分期在Tis 期、T1期的比例高。而两组绝经情况、 淋巴结转移及病理类型比较，差异无统计学意义（p >0.05）。结论患者年龄≤40 岁、肿瘤分期为Tis 及T1期、肿瘤位于乳晕区及内侧象限时易出现超声假阴性。

关键词:乳腺癌;假阴性;乳腺超声

Abstract:

To retrospectively analyze the differences in breast ultrasonograms between false negative and true positive breast cancers, and summarize the common clinical characteristics of such cases. Methods A total of 649 female patients with primary breast cancers pathologically diagnosed in the Affiliated Hospital of North China University of Science and Technology between January 2006 and December 2015 were collected. According to the preoperative sonographic findings, they divided into false negative group and true positive group. The relationships of patients' age, menopausal status, lesion location and size, pathological type and lymph node metastasis with the breast ultrasonographic detection rate of breast cancers were retrospectively analyzed and compared between the two groups. Results The false negative ratio of breast ultrasonography was 6.6%. Compared to the true positive group, the proportions of young patients (≦40 years), the tumors locating in the areola area and the medial quadrant, and the tumors in Tis stage and T1 stage were high in the false negative group. There was no significant difference in the menopausal status, the lymph node metastasis or the pathological type between the two groups (p > 0.05). Conclusions False negative ultrasonograms easily appear when the patients are 40 years old or younger, the tumors are in Tis stage and T1 stage, and the tumors are located in the mammary areola area and the medial quadrant.

Key words:breast cancer; breast ultrasound; false negative