瓣膜置换术后应用左西孟坦的临床观察

Clinical application of Levosimendan after cardiac valve replacement

摘要:

 摘要：目的  观察左西孟坦在瓣膜置换术后应用的临床效果。方法  二尖瓣置换术患者60例，随机分为常规治疗组和左西孟坦组，每组30例。术后常规治疗组给予强心、利尿等常规治疗，左西孟坦组在常规治疗组治疗基础上给予左西孟坦。比较两组患者治疗效果及恢复情况。结果  术后左西孟坦组心肌损伤反应和呼吸机辅助时间与常规治疗组比较，差异有统计学意义（P <0.05），左西孟坦组心肌损伤反应和呼吸机辅助时间减少；左西孟坦组重症加强护理病房（ICU）停留时间与常规治疗组比较，差异有统计学意义（P <0.05），左西孟坦组ICU停留时间减少。结论  左西孟坦用于心脏瓣膜置换术后患者可明显改善心功能，减轻心肌损伤反应，且不良反应少，值得临床推广。

Abstract:

Abstract: Objective To observe the clinical application effect of Levosimendan in patients after valve replacement. Methods Sixty patients with mitral valve replacement were randomly divided into routine treatment group (group C) and Levosimendan group (group Z) with 30 cases in each group. The group C received conventional treatment such as cardic stimulants and diuresis, while the group Z received Levosimendan in addition to the conventional treatment. Treatment effect and recovery of the two groups were compared. Results After operation, the myocardial injury response was weakened and the ventilator-assistant and the ICU-stay time was shortened in the group Z compared with the group C, the differences were statistically significant (P < 0.05). Conclusions Levosimendan can significantly improve cardiac function, reduce myocardial injury response and adverse reactions for patients after cardiac valve replacement, and it is worthy of promotion.