枳椇皮提取物对肾结石大鼠的治疗作用

Therapeutic effect of Hovenia acerba extract on renal calculi in rats

摘要:

研究枳椇皮中药灌胃给药后对肾结石大鼠的治疗作用。方法采用乙二醇加氯化铵法复制肾结石病理模型，观察枳椇皮提取物对肾结石大鼠的治疗作用。结果枳椇皮提取物能恢复肾结石大鼠的体重，增加24 h排尿量，促进血液中钙的排泄和代谢，减少肾组织中结石的形成，降低血清尿素氮、肌酐水平，减缓大鼠肾组织因结石引起的损伤和病变。结论枳椇皮提取物对大鼠肾结石有一定的治疗作用，但其确切机制有待进一步研究。

Abstract:

To study the therapeutic effect of intragastric administration of Hovenia acerba bark medicine on renal calculi in rats. Methods The rats were fed with ethylene alcohol and ammonium chloride to induce renal calculi and the effect of Hovenia acerba bark extract on renal calculi was studied. Results Hovenia acerba bark medicine had obvious effect on restoring the weight of rats with renal calculi, increasing the 24-h urinary output, promoting the excretion and metabolism of blood Ca2+, reducing the formation of renal calculi, the concentration of serum urea nitrogen and creatinine, slowing down the rat renal damage and disease caused by stones. Conclusions Hovenia acerba bark extract has certain therapeutic effect on rat kidney stones and its exact mechanism remains to be studied further.