炎性指标与口腔种植修复术患者种植体预后的相关性

Correlation between inflammation indexes and prognosis of implant in patients with oral implant repair

摘要:

摘要：目的  探讨血清C反应蛋白（CRP）、尿脱氧吡啶啉（UDPd）/肌酐（Scr）比值等炎性相关指标与口腔种植修复患者的相关性。方法  前瞻性选取2014年1月-2015年11月在该院接受口腔种植修复的患者50例作为研究组，同时选取50例健康成人作为对照组。主要观察指标为术前1周、术后1周和术后1个月时CRP、UDPd/Scr比值、白细胞、白细胞介素1（IL-1）、白细胞介素6（IL-6）及肿瘤坏死因子-α（TNF-α）。结果  与对照组比较，研究组术后1周和1个月的CRP、UDPd/Scr比值、IL-1、IL-6及TNF-α水平升高（P <0.05）。术后1个月CRP与UDPd/Scr比值呈正相关（r =0.298，P =0.003）。种植骨整合不良患者的CRP、UDPd/Scr、IL-1、IL-6及TNF-α水平高于整合良好患者（P <0.05）。结论  CRP、UDPd/Scr比值、IL-1、IL-6及TNF-α等炎性指标与口腔种植修复术患者种植体预后相关。

Abstract:

Abstract: Objective To investigate the relationships between inflammation-related indexes and prognosis of implant after oral implant repair. Methods Fifty patients with dental implant repair in our hospital from January 2014 to November 2015 were enrolled in this study as the experiment group while 50 healthy adults were enrolled as the control group. CRP, urine deoxypyridinoline/serum creatinine (UDPd/Scr) ratio, white blood cells, interleukin-1 (IL-1), IL-6 and tumor necrosis factor-alpha (TNF-α) were detected 1 week before operation, 1 week and 1 month after operation. Results Compared with the control group, the CRP, IL-1, IL-6 and TNF-α levels, and UDPd/Scr ratio were significantly elevated in the experiment group at 1 week and 1 month after operation (P < 0.05). One month after operation CRP was significantly associated with UDPd/Scr ratio (r = 0.298, P < 0.05). The levels of CRP, UDPd/Scr, IL-1, IL-6 and TNF-α in the patients with poor osseointegration were higher than those in the patients with good osseointegration (P < 0.05). Conclusions CRP, UDPd/Scr, IL-1, IL-6 and TNF-α levels are related to the prognosis of dental implant.