含奥沙利铂化疗方案联合热疗治疗原发性肝癌的临床治疗效果研究

Study on clinical therapeutic effect of Oxaliplatin-containing chemotherapy combined with thermotherapy for primary liver cancer

摘要:

目的 探讨含奥沙利铂化疗方案联合热疗治疗原发性肝癌的临床治疗效果。方法 将90 例原发性肝癌患者随机分为观察组和对照组，每组45 例。对照组给予常规含奥沙利铂化疗方案，观察组在此基础上加用热疗治疗。对比两组患者短期疗效、疼痛缓解水平、免疫细胞变化及不良反应。结果 观察组治疗有效率、疼痛缓解水平与对照组比较，差异有统计学意义（P <0.05），观察组治疗有效率高于对照组，观察组疼痛缓解水平优于对照组患者。治疗后观察组四型免疫细胞（CD4+）、CD4+/CD8+ 及自然杀伤细胞（NK）细胞与对照组比较，差异有统计学意义（P <0.05），观察组高于对照组。观察组消化道反应和肝功能损伤不良反应发生率与对照组比较，差异有统计学意义（P <0.05），观察组低于对照组。结论 热疗联合含奥沙利铂化疗方案治疗原发性肝癌的短期疗效确切且能有效缓解癌痛、免疫损伤及不良反应，具有临床应用价值。

Abstract:

Objective To investigate the clinical therapeutic effect of Oxaliplatin-containing chemotherapy combined with thermotherapy in the treatment of primary liver cancer. Methods Ninety cases of primary liver cancer were randomly divided into observation group and control group, with 45 cases in each group. The patients of the control group were given routine Oxaliplatin-containing chemotherapy, while the patients in the observation group were treated with thermotherapy based on the above treatment. The short-term efficacy, the level of pain relief, the changes of immune cells and the incidence of adverse reactions were compared between the two groups. Results The effective rate of the observation group was significantly higher than that of the control group (χ2 = 5.378, P < 0.05). The level of pain relief in the observation group was significantly better than that in the control group (χ2 = 18.519, P < 0.05). CD4+ T cells, CD4+/CD8+ and NK cells after treatment in the observation group were significantly higher than those in the control group (P < 0.05). The incidences of the adverse reactions of the digestive tract and liver function damage in the observation group were significantly lower than those in the control group (P < 0.05). Conclusions Thermotherapy combined with Oxaliplatin-containing chemotherapy has definite short-term curative effect in the treatment of primary liver cancer and can effectively alleviate cancer pain,immune injury and adverse reactions, therefore has clinical value.