小儿腹部手术后应用生长抑素的疗效观察

Clinical efficacy of postoperative application of somatostatin in children scheduled for abdominal operation

摘要:

目的评估生长抑素应用于小儿腹部手术后的临床疗效和安全性。方法该研究共纳入2014年1月-2016年6月在海南省人民医院行腹部手术的急腹症患儿120例，将其随机分为观察组（60 例）和对照组（60 例）。腹部手术后，对照组给予常规治疗。观察组在常规治疗基础上联合应用生长抑素。比较两组患儿的腹围差、术后24h胃肠管引流和呕吐量、肛门排气时间、住院时间等术后情况；比较两组患儿术后并发症的发生率、生活质量评分，以及患儿和家长对治疗的满意度。结果观察组患儿的腹围差、24 h胃肠管引流和呕吐量、肛门排气时间及住院时间少于对照组（P <0.05）。观察组患儿术后并发症发生率为6.7%，低于对照组患儿术后并发症发生率（18.3%）（P <0.05）。两组患儿术前生活质量评分比较，差异无统计学意义（P >0.05）。术后1 个月，两组患儿的生活质量评分较术前提高（P <0.05）。而且观察组患儿术后生活质量评分高于对照组（P <0.05）。观察组患儿和家长对治疗的满意度为96.7%，高于对照组（81.7%）（P <0.05）。结论小儿腹部手术后应用生长抑素能够有效促进患儿术后胃肠功能的恢复，改善预后，提高生活质量。

Abstract:

Objective To evaluate the clinical efficacy and safety of postoperative application of somatostatin in children scheduled for abdominal surgery. Methods A total of 120 pediatric patients, who were scheduled for abdominal surgery from January 2014 to June 2016 in our hospital due to acute abdomen, were enrolled in this study. The patients were randomly divided into observation group (60 cases) and control group (60 cases). After surgery, the patients in the control group accepted routine treatment, while the patients in the observation group were treated with somatostatin on the basis of routine treatment. The abdominal circumference difference, vomiting and drainage volume of gastrointestinal tube 24 h after surgery, anal exhaust time after surgery and hospitalization time were compared between the two groups. And the incidence of complications was compared between the two groups. Furthermore, the scores of the quality of life and the satisfaction of the treatment in both groups were evaluated and compared. Results The abdominal circumference difference was less, the vomiting and drainage volume of gastrointestinal tube 24 h after surgery was smaller, the anal exhaust time after surgery and the hospitalization time were significantly shorter in the observation group compared to the control group (P < 0.05). The incidence of postoperative complications in the observation group was 6.7%, which was significantly lower than that of the control group (18.3%,P <0.05). There were no statistical differences in the scores of the quality of life between the two groups before operation (P > 0.05). And 1 month after operation, the scores of the quality of life in both groups were significantly higher than those before surgery (P < 0.05). In addition, the scores of the quality of life in the observation group were significantly higher than those in the control group (P < 0.05). The satisfaction of the treatment in the observation group was 96.7%, which was significantly higher than that of the control group (81.7%), the difference was statistically significant (P < 0.05). Conclusions Postoperative application of somatostatin in pediatric patients can effectively promote the recovery of gastrointestinal function, improve the prognosis and the quality of life.