中药治疗痰湿体质脑梗死恢复期患者的疗效研究

Curative effect of traditional Chinese medicine on cerebral infarction patients in rehabilitation period

摘要:

目的 研究中药对痰湿体质脑梗死恢复期神经细胞因子、血小板功能的影响。方法 选取2013年5 月-2015 年12 月于泰安市第一人民医院和山东大学附属省立医院接受治疗的146 例痰湿体质脑梗死康复期患者并随机分为两组，观察组患者接受常规药物治疗、康复训练以及中药复方制剂，对照组患者接受常规药物治疗和康复训练。治疗前后分别评估神经功能、测定神经细胞因子含量及血小板功能指标。结果 治疗后4 和8 周时，两组患者的美国国立卫生院神经功能缺损评分血小板聚集率及血清中CD62p 和PAC-1 的含量均低于治疗前，简易智能精神状态检查量表评分、日常生活活动能力量表评分、血清中脑源性神经营养因子及神经生长因子的含量均高于治疗前。结论 针对痰湿体质的中药能够改善脑梗死恢复期患者的神经功能并增加神经细胞因子分泌、抑制血小板聚集。

Abstract:

Objective To study the effect of traditional Chinese medicine on nerve cell factor and platelet function of phlegm-dampness cerebral infarction patients in rehabilitation period. Methods Totally 146 cases of phlegm-dampness cerebral infarction patients in rehabilitation period in Tai’an First People’s Hospital and Shandong Provincial Hospital Affiliated to Shandong University between May 2013 and December 2015 were randomly divided into two groups. The patients in the observation group received conventional drug treatment, rehabilitation training and traditional Chinese medicine, and the patients in the control group received routine drug treatment and rehabilitation training. Before and after treatment, neurological function of the patients was assessed, nerve cell factor content and platelet function index were determined. Results In 4 and 8 weeks after treatment, NHISS score and serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the two groups were significantly lower than those before treatment, while MMSE score, ADL score, platelet aggregation rate and serum CD62p and PAC-1 levels in the two groups were significantly higher than those before treatment; NHISS score and serum BDNF and NGF levels in the observation group were significantly lower than those in the control group, while MMSE score, ADL score, platelet aggregation rate and serum CD62p and PAC-1 levels in the observation group were significantly higher than those in the control group. Conclusions Traditional Chinese medicine for phlegm dampness constitution can improve the neurological function of the patients with cerebral infarction in rehabilitation period and increase the secretion of cytokines and inhibit platelet aggregation.