不同雾化方法吸入布地奈德对慢性阻塞性肺疾病急性加重期患者胸肺顺应性及动脉血气指标的影响

Effects of budesonide inhalation by different methods on lung and thorax compliance and arterial blood gas in AECOPD patients

摘要:

目的探讨不同雾化方法吸入布地奈德对慢性阻塞性肺疾病急性加重期（AECOPD）患者胸肺顺应性及动脉血气指标的影响。方法83 例慢阻肺急性加重期患者根据随机数字法分成两组，其中，40 例采用空气泵驱动雾化治疗（空气泵驱动组），43 例采用氧驱动雾化治疗（氧驱动组）。对慢阻肺症状评分（CAT）、血气分析指标及胸肺顺应性进行测定。结果治疗前后，空气泵驱动组及氧气驱动组雾化吸入布地奈德在CAT评分、胸肺顺应性（Ct、CI 和Cth）、肺通气指标（FEV1.0、PEF、MIP 和MEP）及血液酸碱度（pH）和动脉血氧分压（PaO2）值比较差异无统计学意义（p >0.05），但空气泵驱动组在改善PaCO2水平上优于氧气驱动组（p <0.05）。结论孟鲁司特钠联合BiPAP呼吸机治疗哮喘-慢性阻塞性肺疾病重叠综合征有较好的临床疗效，值得推广和应用。

Abstract:

To evaluate the effects of budesonide inhalation by different methods on lung and thorax compliance and Arterial blood gas in the AECOPD patients. Methods A total of 83 patients with AECOPD were chosen and were divided into the two group according to the random number table, 40 of them accepted sinus flow pump nebulized budesonide (sinus flow pump group), 43 recieved oxygen drived nebulizer (oxygen drived group). The scores of COPD assessment test, arterial blood gas analysis parameters and lung and thorax compliance were recorded before and after therapy in every groups. Results Before and after treatment, the CAT score, chest compliance (Ct, CI, Cth), pulmonary ventilation index (FEV10, PEF, MIP,MEP) and blood pH had no significant difference in the sinus flow pump group and oxygen drived group (p >0.05), but PaCO2 level was better in the sinus flow pump group than that of oxygen drived group (p < 0.05). Conclusions Sinus flow pump nebulized budesonide is safer than oxygen drived nebulizer for AECOPD who without hypercapnemia.