甲状腺功能亢进症合并急性冠状动脉综合征的影响因素分析

Influencing factors of hyperthyroidism complicated with acute coronary syndrome

摘要:

探讨甲状腺功能亢进症（甲亢）合并急性冠状动脉综合征（ACS）的危险因素。方法选取2010 年1 月-2016 年12 月的甲亢合并ACS 患者及单纯甲亢患者。分别设为ACS 组及对照组，收集患者的性别、年龄、吸烟、生化及冠状动脉造影等临床资料，进行比较及危险因素分析。结果ACS 组甲亢病程较对照组长，甲亢未控制率及平均年龄均较对照组高，且男性患者所占比例亦较对照组高；ACS 组游离三碘甲状腺原氨酸（FT3）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）及脑钠肽（BNP）水平高于对照组；Logistic 回归分析发现，年龄、性别、FT3、高血糖及较长的甲亢病程均为甲亢合并ACS 患者的危险因素。结论多种因素可影响甲亢患者ACS 的发生。

Abstract:

To explore the risk factors of hyperthyroidism complicated with acute coronary syndrome(ACS). Methods The patients with hyperthyroidism complicated with ACS and the patients with hyperthyroidism from January 2010 to December 2016 were enrolled into ACS group and control group respectively. The clinical data including sex, age, smoking, biochemical indexes and coronary angiograms were collected and compared, and the risk factors were analyzed. Results The course of hyperthyroidism in the ACS group was longer than that in the control group, the uncontrol rate of hyperthyroidism was higher that of the control group, the average age was older than that of the control group, and the proportion of the male patients was higher than that of the control group. The levels of FT3, FBG, HbA1c and BNP in the ACS group were significantly higher than those in the control group (p < 0.05). Logistic regression analysis showed that age, sex, FT3, hyperglycemia and longer course of hyperthyroidism were the risk factors of hyperthyroidism complicatd with ACS. Conclusions Many factors can affect the occurrence of ACS in patients with hyperthyroidism.