Abstract:Objective To promote the development and application of the portable surgical navigation system and provide a more effective and feasible diagnostic and treatment method for breast cancer sentinel lymph nodes (SLNs) through comparing the wearable surgical navigation system with the Ming De system. Methods Forty patients with early clinical diagnnose of breast cancer sentinel lymph nodes received ICG as a lymphatic tracer were randomly divided into Google group and Ming De group, which were tested by using the wearable surgical navigation system and the Ming De system, respectively. Two groups of patients underwent conventional SLNB. Results The average time to complete a biopsy was shorter in the Google group than in the Ming De group. The difference was statistically significant (p < 0.05). The detection,accuracy and sensitivity rate of sentinel lymph node in Google group were similar to those in Ming De group,the difference was not statistically significant (p > 0.05). The number of SLNs detected in the Google group was significantly smaller than that in the Ming De group, the difference was statistically significant (p < 0.05).Conclusions Wearable surgical navigation system based on Google glasses is portable, real-time and accurate.Its detection, accuracy and sensitivity rate is not inferior to the Ming De system currently being used. In addition, it has a higher potential in improving the efficiency of surgery to reduce the operation time.