维吾尔族T2DM患者血清空腹C-肽水平与糖尿病家族史的关系

Relation between serum C-peptide level and family history of diabetes mellitus in Uygur patients with type 2 diabetes mellitus

摘要:

探讨维吾尔族2型糖尿病（T2DM）患者血清空腹C- 肽水平与糖尿病（DM）家族史、临床特征的关系，进一步了解DM家族史对T2DM患者残余β细胞功能的影响。方法选取新疆医科大学第一附属医院确诊为T2DM 的维吾尔族患者391 例，根据有无DM 家族史和DM 病程进行分组，并比较各组一般资料、血清空腹C-肽水平及血糖、血脂等相关指标。结果391例患者中有DM家族史123 例（31.46%），无DM家族史268 例（68.54%）；两组在DM 病程、体重指数（BMI）、糖化血红蛋白（HbA1c）、空腹血糖、血压、血脂及并发症等方面比较，差异无统计学意义（p >0.05），有DM 家族史的患者发病年龄较小，收缩压水平低，血清空腹C-肽浓度低；在调整DM 病程、BMI、HbA1c、空腹血糖、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白及高密度脂蛋白等指标后，血清空腹C- 肽水平与DM家族史呈负相关（p <0.05）。结论在维吾尔族T2DM患者中，DM 家族史与血清空腹C- 肽水平的逐步下降相关。

Abstract:

To investigate the relationship of fasting C-peptide level with family history of diabetes and clinical characteristics of diabetes mellitus (T2DM) patients and to further understand the effect of family history of diabetes on residual β-cell function in patients with T2DM. Methods A total of 391 Uyghur patients diagnosed as T2DM in a top three hospital in Urumqi were collected, and grouped according to DM family history and DM duration. The general information, fasting C-peptide level, blood glucose, blood lipid and other related indicators were compared between the groups. Pearson correlation analysis was used to determine the associations between various indicators; multiple regression models were used to determine the influence factors of fasting serum C-peptide. Results Of the 391 patients, 123 cases (31.46%) had and 268(68.54%) did not have family history of diabetes. Compared with the no-DM-family-history group, the patients of the DM-family-history group had younger age of onset, lower systolic blood pressure, and lower fasting Cpeptide concentration. However, no significant difference was observed in DM duration, body mass index (BMI), HbA1c, blood pressure, blood lipids or complications between the two groups. After adjustment for DMduration, BMI, HbA1c, fasting blood glucose, systolic blood pressure, diastolic blood pressure, total cholesterol (TC), triacylglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL), fasting C-peptide level was negatively correlated with family history of diabetes (p < 0.05). Conclusions In the Uyghur patients with T2DM, a family history of diabetes is significantly correlated with the decrease of serum fasting C-peptide level.