复发性流产患者血清维生素D水平与自身免疫抗体、淋巴细胞亚群的关系研究

Study on relationship between serum vitamin D level and autoantibodies or lymphocyte subsets in patients with RSA

摘要:

目的探讨复发性流产（RSA）患者血清维生素D 水平与自身免疫抗体、淋巴细胞亚群的关系。方法回顾性分析RSA患者125 例，根据血清25 羟维生素D[25（OH）D]水平，分为25（OH）D 正常水平组50 例、25（OH）D低水平组75 例，分析两组自身免疫抗体阳性率及淋巴细胞亚群水平。结果25（OH）D低水平组抗心磷脂抗体（ACA）、抗核抗体（ANA）的阳性率及甲状腺过氧化物酶（TPO）抗体阳性率均高于25（OH）D正常水平组，差异有统计学意义（P <0.05）；25（OH）D低水平组外周血CD3+CD4+、CD4+/CD8+、CD19+及CD56+百分率均高于25（OH）D正常水平组，差异有统计学意义（P <0.05）。结论RSA 患者中维生素D 缺乏的比例较高，维生素D 缺乏的RSA 患者ACA、ANA 及TPO 抗体阳性率较高，RSA 维生素D 水平与CD4+T 细胞、B 细胞及NK细胞免疫平衡有关。

Abstract:

Objective To investigate the relationship between serum vitamin D level and autoantibodies or lymphocyte subsets in patients with recurrent spontaneous abortion (RSA). Methods A total of 125 patients with RSA were included in a retrospective analysis. According to the serum levels of 25-hydroxy vitamin D [25-(OH)-D], the patients were divided into [25-(OH)-D] normal group including 50 cases and [25-(OH)-D] low level group including 75 cases. The positive rate of autoantibodies and the level of lymphocyte subsets in the two groups were analyzed. Results Compared with the [25-(OH)-D] normal group, the positive rates of anticardiolipin antibody (ACA), antinuclear antibody (ANA) and thyroid peroxidase (TPO) antibody were higher in the [25-(OH)-D] low level group, the difference was statistically significant (P < 0.05); the percentages of (CD3+/ CD4+) T, CD4+/CD8+, CD19+ B cells and CD56+ natural killer (NK) cells were higher in the [25-(OH)-D] low level group, the difference was statistically significant (P < 0.05). Conclusions The rate of vitamin D deficiency is higher in women with RSA. The positive rates of ACA, ANA and TPO are higher in RSA women with vitamin D deficiency. The vitamin D level in women with RSA is related to CD4+ T cells, B lymphocytes and the balance of NK cells.