偏侧面肌痉挛患者的情感、睡眠和认知状态的研究

Study of emotion, sleep and cognitive status in patients with lateral hemifacial spasm

摘要:

目的探讨偏侧面肌痉挛（HFS）患者的情感、睡眠和认知状态的情况。方法选取2015年1 月-2017 年2 月在昆明医科大学第一附属医院神经内科门诊就诊的偏侧面肌痉挛患者30 例，同时纳入年龄、性别和文化程度与患者相匹配的30 例为健康对照组，对两组受试者进行14 项版汉密尔顿焦虑量表（HAMA）、17 项版汉密尔顿抑郁量表（HAMD）、匹兹堡睡眠质量指数量表（PSQI）和安登布鲁克认知功能检查（ACE-Ⅲ）测评，将所获数据录入SPSS 21.0软件进行对比分析。结果①焦虑评估显示，患者焦虑的发生率较健康对照组高，差异有统计学意义（P <0.05）；焦虑的发生与痉挛程度无关，差异无统计学意义（P >0.05）；女性患者发生焦虑的比例高于男性患者，但差异无统计学意义（P <0.05）；病程≥10 年的患者发生焦虑的比例高于病程<10 年的患者，差异有统计学意义（ P<0.05）；②抑郁评估显示，患者抑郁的发生率较健康对照组高，差异有统计学意义（P <0.05）；抑郁的发生与痉挛程度无关，差异无统计学意义（P >0.05）；女性患者发生抑郁的比例高于男性，差异有统计学意义（P <0.05）；病程≥10 年的患者发生抑郁的比例高于病程<10 年的患者，差异有统计学意义（P <0.05）；③睡眠评估显示，患者组与对照组受试者的PSQI主观睡眠质量、睡眠潜伏期、睡眠持续性、白天功能紊乱和PSQI 总分比较差异有统计学意义（P <0.05）；习惯性睡眠效率、睡眠紊乱、使用睡眠药物差异无统计学意义（P >0.05）；④认知评估显示，病例组与健康对照组受试者的注意力、记忆力、语言流利性、语言、视空间和ACEⅢ总分比较差异无统计学意义（P >0.05）。结论偏侧面肌痉挛患者广泛存在焦虑、抑郁情绪和睡眠问题；应加强对面肌痉挛患者的情感、睡眠质量的关注，以提高患者的生活质量。

Abstract:

Objective To investigate emotion, sleep and cognitive status of patients with hemifacial spasm (HFS). Methods Thirty patients with HFS from our hospital were enrolled in the study from January 2015 to February 2017. Another 30 healthy individuals matched with age, sex and education level were collected simultaneously. The 14-version hamilton anxiety scale (HAMA), the 17-version Hamilton depression scale (HAMD), the Pittsburgh sleep quality index (PSQI) and ADDENBROOKE'S cognitive function test ACE-Ⅲ were conducted for both groups, and the data were comparatively analyzed with SPSS 21.0 software. Results Anxiety assessment showed that anxiety incidence of the patients was higher than that of the control group,which was statistically significant ( P<0.05); the anxiety incidence was not related to the degree of spasms,which was not statistically significant ( P>0.05); the proportion of female patients with anxiety was higher than that of male patients, but the difference was not statistically significant ( P>0.05); The proportion of patients with anxiety ≥10 years was significantly higher than that of patients < 10 years, the difference was statistically significant (P < 0.05); depression assessment showed that the incidence of depression was significantly higher than that of the control group ( P <0.05); the incidence of depression was not related to the degree of spasms, without statistically significant ( P >0.05); the proportion of depression in female patients was significantly higher than that of male ( P <0.05); the proportion of patients with depression ≥10 years was obviously higher than that of patients < 10 years ( P <0.05); sleep assessment showed that subjective sleep quality, sleep latency, sleep persistence, daytime dysfunction and total score were statistically different between the patient group and the control group ( P <0.05); while habitual sleep efficiency, sleep disorder, sleep medication were not statistically different between them ( P >0.05); cognitive function assessment showed that attention, memory,language fluency, language, visual space and ACE Ⅲtotal score were not statistically different between the two groups. Conclusions Anxiety, depression and sleep problems widely exist in patients with hemifacial spasm. Emotion and sleep quality of patients with facial muscle spasms should be concerned to improve their quality of life.