Abstract:Objective To investigate the therapeutic effect of endoloop combined with metal clips in the gastroscopic treatment of gastric perforation. Methods A total of 42 patients diagnosed with gastric submucosal tumor (GSMT) who received endoscopic treatment complicated gastric perforation were included retrospectively in this study. Patients were treated randomly with either of the following two ways: endoloop plus metal clips (endoloop group) or metal clips only (clip group). Results Endoscopic operation was successfully performed in both groups. No significant difference in time of procedure between two groups was observed (P > 0.05).Quantity of clips applied in the clip group was much more compared with the endoloop group. Time of duration for gastric tube intubation and fasting, application of antibiotics, postoperative hospital stay, and overall costing in endoloop group was significantly decreased compared with the clip group, respectively (P <0.05). There were no dramatic difference in postoperative complications between two the groups (P > 0.05). All patients were recovered with satisfactory healing of surgical wound after 3 months. Conclusions Application of endoloop combined with metal clips shows promising therapeutic effect in endoscopic treatment of gastric perforation.