男性雄性激素缺乏对生命质量影响的初步分析

Effect of androgen deficiency on quality of life of male

摘要:

目的探究雄性激素缺乏对男性生命质量的影响。方法分层整群抽样的方法抽取遵义市1 166 例成年男性作为调查对象，每位调查对象完成基本信息、生命质量量表（SF-36）填写，并完成身高体重测量、血清激素水平检测。排除有疾病史的对象428 例，剩余738 例纳入分析。对生命质量生理领域、心理领域及总分的影响因素采用多元线性回归进行筛选。筛选出的影响因素进行组间方差分析比较。结果多元线性回归结果显示，纳入观察的4 个雄性激素指标中，睾酮分泌指数与心理领域评分独立关联（b=10.880， P=0.033）。此外，年 龄、结扎及文化水平分别与生理领域评分独立关联；结扎、体质指数及婚姻状态分别与心理领域评分独立关联；年龄、结扎、文化水平及体质指数分别与生命质量总分独立关联（均P<0.05）。方差分析结果显示睾酮分泌指数在生理职能、社会功能及情感职能维度有差异，且激素缺乏组的评分低于正常组。结论较好的睾酮分泌能力可能是男性生命质量的保护因素；此外较高的体质指数及文化水平也可能是生命质量的保护因素，而高龄、结扎史则可能是男性生命质量的危险因素。

Abstract:

Objective To explore the impacts of androgen deficiency on quality of life of male. Methods A total of 1,166 male participants were collected from Zunyi city by stratified cluster sampling method. Basic information and quality of life scale (SF-36) were taken from each subject, and physical measurement and serum hormone test were also required. Four hundred and twenty-eight subjects with history of disease were excluded, remaining 738 qualified subjects brought into the analysis. Multiple linear regression was performed to filtrate the influence factors of quality of life in physical component summary, mental component summary and total score. The differences in filtrated factors were compared by analysis of variance (ANOVA) between groups. Results Multiple linear regression revealed that testosterone secretion index was in independent association with mental component summary score among those 4 androgen criteria brought into the analysis (b = 10.880, P= 0.033). In addition, indexes of age, vasectomy and education level were independently associated with physical component summary score respectively; vasectomy, BMI and marriage status were independently associated with mental component summary score respectively; age, vasectomy, education level and BMI were independently associated with total score respectively (all of the above P< 0.05). The ANOVA results revealed that the differences of testosterone secretion index were statistically significant in physical,emotional and social functions; and the score of hormone deficiency group was lower than that of normal group. Conclusions A better ability of testosterone secretion, a higher BMI and a higher education level might be protective factors of quality of life of male; while advanced age and history of vasectomy might be the risk factors.