纳洛酮联合依达拉奉对急性脑出血患者的疗效及对血浆FIB、D-D 水平的影响

Effect of Naloxone combined with Edaravone on acute cerebral hemorrhage and plasma FIB and D-D levels of patients

摘要:

目的 探究纳洛酮联合依达拉奉对急性脑出血患者的疗效及对血浆纤维蛋白原（FIB）、D- 二聚体（D-D）水平的影响。方法 采用前瞻性研究法，选取2015 年3 月-2017 年3 月该院收治的150 例急性脑出血患者，随机平均分为研究组及对照组，每组各75 例。对照组患者使用手术治疗，在此基础上研究组加用纳洛酮联合依达拉奉，治疗14 d 后，比较两组患者治疗总有效率及不良反应发生率，比较两组治疗前后血清炎症因子、血清氧化应激产物、血浆FIB 及D-D 水平，同时对比两组治疗前后美国国立卫生研究院卒中量表（NIHSS）及Fugl-Meyer 评分。结果 研究组治疗总有效率90.67%，高于对照组76.00%（P <0.05），研究组Fugl-Meyer 评分、血浆FIB 水平高于对照组（P <0.05），研究组NIHSS 评分、血清炎症因子、血清氧化应激产物及D-D 水平低于对照组（P <0.05）。结论 纳洛酮联合依达拉奉能有效治疗急性脑出血，可降低血清炎症因子及氧化应激产物水平，同时能够改善凝血功能，对患者神经功能缺损情况呈正性作用。

Abstract:

Objective To study the effect of Naloxone combined with Edaravone on the treatment of acute cerebral hemorrhage and the level of plasma fibrinogen (FIB) and D-Dimer (D-D). Methods Totally 150 patients with acute cerebral hemorrhage in our hospital from March 2015 to March 2017 were randomly divided into study group and control group with prospective study (75 cases in each group). The control group was treated with surgery. The study group was treated with extra Naloxone combined with Edaravone apart from surgery. Fourteen days after treatment,total effective rate, incidence of adverse reactions, serum inflammatory factors, serum oxidative stress products, plasma FIG and D-D levels were compared between the two groups, as well as NIHSS and Fugl-Meyer scores pre- and posttreatment. Results Total effective rate of the treatment group was 90.67%, which was higher than the control group (P < 0.05); levels of plasma FIB, Fugl-Meyer scores of the study group were higher than the control group (P < 0.05);the NIHSS score, serum inflammatory factors, serum oxidative stress and the level of D-D in the study group were lower than the control group (P < 0.05). Conclusions Naloxone combined with Edaravone can be effective in the treatment of acute cerebral hemorrhage, reduce the serum inflammatory cytokines and levels of oxidative stress products and improve the coagulation function, which shows a positive effect on patients with neurological function.