MICA基因多态性及单倍型多样性与卵巢癌的易感关联性研究

Association between MICA gene polymorphism and haplotype diversity with ovarian cancer

摘要:

探讨中国南方汉族人群MICA等位基因多态性和卵巢癌发生之间的关联。方法采用PCRSSP及PCR-SBT方法对外周血标本的目的基因进行检测。结果中国南方汉族卵巢癌组患者外周血标本中检测到11 种MICA等位基因；和对照组相比较， MICA*010 等位基因在卵巢癌组患者中分布频率升高。卵巢癌患者组中检测到5种MICA-STR 等位基因，但其与对照组比较，差异无统计学意义；卵巢癌患者组MICA* 010/010纯合子出现率增加，提示其对卵巢癌可能易感（OR=14.82，95%CI：1.89，115.94，p <0.05）。结论MICA等位基因多态性与中国南方汉族卵巢癌的发生有相关性。

Abstract:

To study the association between the MICA gene polymorphism and haplotype diversity with the susceptibility of ovarian cancer. Methods PCR-SSP and PCR-SBT were used to analyze the gene polymorphism and haplotype diversity of MICA in ovarian cancer patients and healthy individuals. Results Eleven MICA allele genes were found in the south China ovarian cancer patients, and the frequency of MICA * 010 was higher in south China ovarian cancer patients than in healthy controls, presenting genic susceptibility to ovarian cancer (OR = 6.43, 95% CI: 3.51, 11.76,p < 0.05). Five MICA-STR alleles were detected, but there was no significant difference between the case and the control. Compared to the control group, the distribution frequency of MICA * 010/010 was significantly high and it is probably a susceptibility genotype to ovarian cancer (OR = 14.82, 95% CI: 1.89, 115.94,p < 0.05). Conclusions MICA allele gene polymorphism and haplotype diversity may be associated with ovarian cancer.