铅中毒和驱铅药物的研究进展

Research progress on lead poisoning and development of deleading reagents

摘要:

铅中毒是一种铅暴露引起的直接损害神经系统并累及多种器官的疾病。由于铅在日常生活中应用广泛，铅中毒已经成为一种常见疾病。本研究就铅中毒及其对神经、造血、骨骼、生殖系统及肾脏损伤做综述，并描述应用于驱铅药物研究的细胞和动物模型以及阐述常用驱铅药物的利弊，重点介绍了通过阻断肝肠循环治疗铅中毒的研究。

Abstract:

Lead poisoning is a disease caused by lead exposure which can directly damage the nervous system and other organs. Since lead is widely used in daily life, lead poisoning has become a common disease. This paper reviews lead poisoning and its damages in the nerve system, hematopoietic system, skeletal system, reproductive system and kidneys, also describes some cell and animal models of lead poisoning for deleading drug research, and explains the advantages and disadvantages of the commonly-used deleading drugs. Importantly, this review introduces a new concept of therapeutics of lead poisoning by blocking the enterohepatic circulation.