双源CT容积测定评估肺癌患者肺功能的应用

Application of volume measurement with dual source CT in evaluating pulmonary function of lung cancer patients

摘要:

目的应用双源CT后处理技术计算肺癌患者吸气末和呼气末容量参数，并与传统肺功能检查（PFT）参数相对比，探讨其评价肺功能中的意义。方法对32 例肺癌患者，术前1周内行肺功能检查及深吸气相和深呼气胸部CT 扫描，采用SIEMENS 工作站Volume 及Pulmo 模块软件进行扫描后处理，得到吸气末和呼气末的肺容积。将CT 后处理数据与肺功能检查主要数据相比较，采用Pearson分析相关性。结果肺癌患者术前吸气相和呼气相全肺容积差值（Vin-Vex）与肺总量（TLC）、第1秒用力肺活量的实测值FEV1、用力肺活量实际值（FVC）呈正相关（r =0.80、0.91和0.82， P<0.05），CT 扫描获得的吸气相容积值（Vin）与肺总量（TLC）呈正相关（r =0.91，P <0.05）。呼气相全肺容积值（Vex）与残气量（Rv）呈正相关（r =0.79，P <0.05）。结论CT 后处理技术在肺癌围手术期中的应用，对肺癌患者肺功能的评估提供新的可能，可以作为常规肺功能检查的补充。

Abstract:

Objective To use dual source CT post -processing technology to compute the volume parameters in deep inspiration and deep expiration period of lung cancer patients respectively; to compare the results with that of traditional pulmonary function test (PFT), and to investigate its significance in the evaluation of pulmonary function. Methods A total of 32 cases of lung cancer were performed PFT and CT in both deep inspiration and deep expiration period one week before surgery. The post-scan process with the Volume and Pulmo Software of SIEMENS Workstation was performed to work out the lung volumes in deep inspiration and deep expiration period. SPSS 19.0 was utilized to analyze the correlation between data from CT post-scan process and PFT. Results Total lung volume difference between deep inspiration and deep expiration period (Vin-Vex) in lung cancer patients was in positive correlation with total lung capacity (TLC),forced expiratory volume in the first second (FEV1) and the forced vital capacity (TLC), respectively (r = 0.80,0.91 and 0.82,P < 0.05). Vin was in positive correlation with TLC (r = 0.91, P< 0.05) and Vex was in positive correlation with the residual volume (RV) (r = 0.79,P < 0.05). Conclusion CT post-processing technology is a possible method to evaluate the pulmonary function before lung cancer surgery, which can beused as a supplement of routine PFT.