骨质疏松症与冠状动脉病变严重程度的相关性分析

Correlation analysis between osteoporosis and severity of coronary artery disease

摘要:

目的 探讨骨质疏松症与冠状动脉病变严重程度的相关性，为早期根据骨质疏松筛查冠心病高危人群提供相关科学依据。方法 选取2015 年1 月-2017 年1 月于江苏省南通市第一人民医院收治的首次行冠状动脉造影并明确为冠心病的300 例患者作为研究对象，回顾性分析骨密度测量结果并将其分为骨质疏松组（n =102）与非骨质疏松组（n =198），同时分析骨质疏松与反应冠状动脉病变严重程度相关指标（冠状动脉狭窄程度、冠状动脉钙化程度）的相关性。结果 骨质疏松组患者冠状动脉狭窄程度高于非骨质疏松组，差异有统计学意义（P <0.05）；骨质疏松组患者冠脉单支病变比例低于非骨质疏松组，且冠状动脉多支病变比例高于非骨质疏松组（P <0.5）；骨质疏松组患者冠状动脉钙化程度高于非骨质疏松组，差异有统计学意义（P <0.05）；骨质疏松组患者轻度钙化比例低于非骨质疏松组，且冠脉中度钙化、重度钙化比例高于非骨质疏松组（P <0.05）；骨质疏松与冠状动脉狭窄程度、冠状动脉钙化程度均呈正相关（P <0.05），Logistic 回归分析显示骨质疏松是冠心病存在的独立危险因素。结论 骨质疏松与冠状动脉狭窄程度、冠状动脉钙化程度独立相关，与冠脉病变严重程度联系密切。

Abstract:

Objective To investigate the correlation between osteoporosis and the severity of coronary artery disease, and to provide a relevant scientific evidence for the screening of high-risk groups of CHD at early stage.Methods From January 2015 to January 2017, 300 patients with coronary heart disease were treated with coronary angiography for the first time in our hospital. The results of bone mineral density measurement were analyzed retrospectively and divided into osteoporosis group (n = 102) and non osteoporosis group (n = 198). The correlation between osteoporosis and the severity of coronary artery disease (the degree of coronary stenosis and the degree of coronary artery calcification) was analyzed. Results The degree of coronary stenosis in the osteoporotic group was significantly higher than that in the non osteoporosis group, and the difference was statistically significant (P < 0.05);proportion of osteoporosis in patients with single vessel coronary artery disease was lower than the non osteoporosis group, and that of multivessel coronary disease was higher in osteoporosis group (P < 0.05); osteoporosis group of patients with coronary artery calcification was significantly higher than non osteoporosis group, the difference was statistically significant (P < 0.05); proportion of osteoporosis group was less than the non osteoporosis patients for mild calcification osteoporosis while proportion of moderate and severe calcification were higher in osteoporosis group (P < 0.05); osteoporosis was positively correlated with the degree of coronary stenosis and coronary artery calcification (P < 0.05). Logistic regression analysis showed that osteoporosis was an independent risk factor for coronary heart disease. Conclusions Osteoporosis is related to the degree of coronary stenosis and coronary artery calcification, and is closely related to the severity of coronary artery disease.