不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和IL-2水平的影响

Effects of different anesthesia methods on perioperative T lymphocyte subsets and IL-2 level in ovarian cancer patients

摘要:

目的探讨不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和白细胞介素2（IL-2）水平的影响。方法选取2013 年1 月-2016 年12 月该院行卵巢癌根治术的160 例患者作为研究对象，根据随机数字法分为全身麻醉组和硬膜外麻醉组，每组80 例。测量两组患者的外周血T淋巴细胞亚群含量及其相关细胞因子IL-2水平。结果全身麻醉组与硬膜外麻醉组患者年龄、体重、手术时间、术中出血量、输液量比较，差异无统计学意义（P >0.05）。不同时间的CD3+、CD4+、CD4+/CD8+水平有差异（P <0.05）；全身麻醉组的CD3+、CD4+、CD4+/CD8+水平低于硬膜外麻醉组（P <0.05）；全身麻醉组和硬膜外麻醉组的CD3+、CD4+、CD4+/CD8+变化趋势有差异（P <0.05）。不同时间的IL-2 水平有差异（P <0.05）；全身麻醉组的IL-2水平低于硬膜外麻醉组（P <0.05）；全身麻醉组和硬膜外麻醉组的IL-2 水平变化趋势有差异（P <0.05）。结论硬膜外麻醉可减轻其对卵巢癌根治术患者围手术期细胞免疫功能的抑制作用。

Abstract:

Objective To investigate the effect of different anesthesia methods on perioperative T lymphocyte subsets and IL-2 level in ovarian cancer patients. Methods A total of 160 patients with ovarian cancer who underwent radical surgery in our hospital from January 2013 to December 2016 were selected as the subjects and divided into general anesthesia group and epidural anesthesia group according to the random number method, each group had 80 cases. The levels of peripheral blood T lymphocyte subsets and IL-2 were measured in the two groups. Results There was no significant difference in age, body weight, operation time, intraoperative blood loss or infusion volume between the general anesthesia group and the epidural anesthesia group (P > 0.05). The levels of CD3+, CD4+ and CD4+/CD8+ were different at different time points (P <0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in the general anesthesia group were lower than those in the epidural anesthesia group (P < 0.05). The change trends of CD3+, CD4+ and CD4+/CD8+ in the general anesthesia group and the epidural anesthesia group were different (P < 0.05). There were differences in the IL-2 levels at different time points (P < 0.05). The level of IL-2 in the general anesthesia group was lower than that in the epidural anesthesia group (P < 0.05). There was significant difference in the change of IL-2 between the general anesthesia group and the epidural anesthesia group (P < 0.05). Conclusions Epidural anesthesia has less inhibitory effect on perioperative cellular immune function in patients with ovarian cancer radical surgery.