PHDs-HIFs-pVHL 通路在类风湿关节炎中的研究进展

Systemic Rreview on PHDs-HIFs-pVHL pathway in rheumatoid arthritis

摘要:

缺氧诱导因子（HIFs）是对细胞低氧敏感的特异性转录因子，其活性受脯氨酸羟化酶（PHD）及 希佩尔林道病肿瘤抑制蛋白（pVHL）调控。在低氧条件下，PHDs 的活性受到抑制，pVHL 发生失活，导致HIFs 的降解受到抑制，HIFs 表达增加，参与低氧相关病理生理过程。该文总结PHDs-HIFs-pVHL 在类风湿关节炎中的研究进展，以期为类风湿关节炎的发病机制以及治疗研究提供新的思路。

Abstract:

Hypoxia-inducible factor (HIF) is a specific transcriptional factor sensitive to hypoxia condition, which is regulated by prolyl hydroxylase domain (PHDs) and von-Hippel-Lindau tumor suppressor protein (pVHL).In hypoxia condition, the activity of PHDs and pVHL is inhibited which is reported to downregulate the degradation of HIFs and increase the expression of HIFs. Increased HIFs paly an important role in the physiological and pathological processes of hypoxia-induced disease. In this review, we summarize the recent advances in the PHDs-HIFs-pVHL pathway in rheumatoid arthritis, hopefully providing a new insight into the pathogenesis and treatment of rheumatoid arthritis.