糖尿病合并脑梗死患者血清HMGB1 水平及其意义

Serum HMGB1 level in patients with diabetes mellitus complicated with cerebral infarction and its significance

摘要:

目的 观察糖尿病合并脑梗死患者血清高迁移率族蛋白B1（HMGB1）及其他血清指标水平，探讨血清HMGB1 与其他血清指标的关系。方法 选择该院糖尿病合并脑梗死患者60 例作为糖尿病合并脑梗死组，糖尿病患者60 例作为糖尿病组，健康体检者60 例作为对照组，收集3 组患者的临床资料、血清HMGB1 及其他血清指标水平。结果 糖尿病合并脑梗死组和糖尿病组患者血清HMGB1、高敏C 反应蛋白（hs-CRP）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、稳态胰岛素评价指数（HOMA-IR）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）水平高于对照组（P <0.05），血清高密度脂蛋白胆固醇（HDL-C）水平低于对照组（P <0.05），糖尿病合并脑梗死组患者血清HMGB1、hs-CRP、FBG、HbA1c、FINS、HOMA-IR、TG、TC、LDL-C 水平高于糖尿病组（P <0.05），血清HDL-C 水平低于糖尿病组（P <0.05）。糖尿病合并脑梗死患者血清HMGB1 与血清hs-CRP、FBG、HbA1c、FINS、HOMA-IR、TG、TC、LDL-C 水平呈正相关（P <0.05），与血清HDL-C 水平呈负相关（P <0.05）。多因素分析结果显示，FINS、HOMA-IR、TG、TC、LDL-C 是血清HMGB1 的影响因素（P <0.05）。结论 糖尿病合并脑梗死患者血清HMGB1 水平升高，血清HMGB1 与hs-CRP、血糖、血脂指标有关，FINS、HOMA-IR、TG、TC、LDL-C 是血清HMGB1 的影响因素。

Abstract:

Objective To observe the serum high mobility group box protein B1 (HMGB1) and other serum markers in patients of diabetes complicated with cerebral infarction, and to explore the relationships between serum HMGB1 and other serum markers. Methods Sixty patients of diabetes complicated with cerebral infarction were selected as the diabetes complicated with cerebral infarction group, 60 cases of diabetes were selected as diabetic group, 60 cases of healthy subjects were selected as control group. The clinical data and serum levels of HMGB1 and other markers in the patients of the three groups were collected. Results The serum levels of HMGB1, highsensitivity C-reactive protein (hs-CRP), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), fasting insulin (FINS), insulin resistance index (HOMA-IR), triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) in the patients of the diabetes complicated with cerebral infarction group and the diabetic group were higher than those in the control group (P < 0.05); the serum levels of high-density lipoprotein cholesterol (HDL-C) were lower than that in the control group (P < 0.05). The serum levels of HMGB1, hs-CRP, FBG, HbA1c, FINS, HOMA-IR, TG, TC and LDL-C in the patients of the diabetes complicated with cerebral infarction group were higher than those in the diabetic group (P < 0.05); the serum HDL-C level was lower than that in the diabetic group (P < 0.05). In the diabetes complicated with cerebral infarction group, serum HMGB1 was in positive correlations with serum levels of hs-CRP, FBG, HbA1c, FINS, HOMA-IR, TG, TC and LDL-C (P < 0.05), but negatively correlated with serum HDL-C level (P < 0.05). The results of multivariate regression analysis showed that FINS, HOMA-IR, TG, TC and LDL-C were the influencing factors of serum HMGB1 (P < 0.05). Conclusions The level of serum HMGB1 increases in the patients with diabetes complicated with cerebral infarction. The serum HMGB1 is related to the levels of hs-CRP and blood glucose and lipid indexes. The FINS, HOMA-IR, TG, TC and LDL-C are the influencing factors of serum HMGB1.