安胃疡胶囊联合雷贝拉唑治疗消化性溃疡疗效及对患者血浆胃泌素与胃动素的影响

Effect of Anweiyang capsules in combination with Rabeprazole on peptic ulcer and serum levels of gastrin and motilin

摘要:

目的  探讨安胃疡胶囊联合雷贝拉唑治疗消化性溃疡（PU）疗效及对患者血浆胃泌素与胃动素的影响。方法  120例符合纳入标准的PU患者随机分为对照组（n =60）和治疗组（n =60）。对照组给予雷贝拉唑+阿莫西林+克拉霉素治疗，观察组在对照组的基础上联合应用安胃疡胶囊治疗。观察比较两组治疗疗效、幽门螺杆菌（Hp）根除率、血浆胃泌素、胃动素水平及不良反应发生情况。并随访6个月，比较两组复发率。结果  治疗组的治疗总有效率和Hp根除率分别为96.7%和96.7%，明显高于对照组85.0%的总有效率和86.7%的Hp根除率（P <0.05）。治疗后，与对照组比较，治疗组胃泌素及胃动素水平明显降低（P <0.05）。治疗过程中，两组均未出现严重不良反应，不良反应发生率组间比较差异无统计学意义（P >0.05）。随访6个月，观察组的复发率为5.0%，明显低于对照组16.7%的复发率（P <0.05）。结论  安胃疡胶囊联合雷贝拉唑治疗PU疗效可靠，具有较高的治疗有效率及Hp根除率，同时可以降低血浆胃泌素及胃动素水平，并减少疾病复发，且不良反应轻微，为临床治疗消化性溃疡提供了新的理论基础。

Abstract:

Objective To investigate the clinical effect of Anweiyang capsules in combination with Rabeprazole on peptic ulcer (PU) and serum levels of gastrin and motilin. Methods A total of 120 cases of PU meeting the inclusion critera were randomly divided into two groups with equal number. The patients of the control group were treated with Rabeprazole, Amoxicillin and Clarithromycin, while the patients of the treatment group were given Anweiyang capsules in combination with Rabeprazole, Amoxicillin and Clari-thromycin. Then, the curative efficacy, Hp eradication rate, serum levels of gastrin and motilin and adverse reactions were observed and compared between both groups. And recurrence rate was compared after 6-month follow-up. Results The treatment group had a therapeutic efficiency ratio of 96.7% and a Hp eradication rate of 96.7%, which was respectively higher than that of 85.0% and 86.7% in the control group (P < 0.05). Compared with the control group after the treatment, gastrin and motilin levels were statistically lower in the treatment group (P < 0.05). During the treatment, there was no case of severe adverse reaction, and the incidence of adverse reactions in the two groups was not statistically different (P > 0.05). After follow-up for six months, the recurrence rate in the treatment group was 5.0%, which was statistically lower than 16.7% in the control group (P < 0.05). Conclusions Combined treatment of Anweiyang capsules with Rabeprazole is effective for PU, which has relatively high therapeutic efficiency and eradication rate of Hp. And it could significantly lower serum levels of gastrin and motilin, and reduce recurrence rate with few adverse reactions.