Abstract: Objective To compare closed continuous irrigation and drainage, open drainage and artificial skin vacuum sealing drainage, and to discuss the clinical application value of closed continuous irrigation and drainage in the treatment of postoperative incision infection. Methods 104 cases of patients with postoperative incision infection received and cured in the hospital from June 2009 to December 2014 were selected. They were divided into 3 groups for comparison: Group A (36 cases); Group B (34 cases); Group C (34 cases). And the three groups were followed by closed continuous irrigation and drainage, open drainage and artificial skin vacuum sealing drainage. Results For the frequency of dressing change, healing time and hospital stays, the differences between Group B, Group C and Group A had statistical significance (P < 0.05); for the clearance time of incision bacterial culture, the differences between Group A and Group B had statistical significance (P < 0.05), while the differences between Group A and Group C had no obvious statistical significance (P > 0.05). For the procalcitonin, white blood cell count, erythrocyte sedimentation rate (ESR) and other statistical results of the three groups, the data differences between Group B, Group C and Group A had no obvious statistical significance (P > 0.05) before the treatment, while the differences of the data between Group A and Group B had statistical significance (P < 0.05) in 7 days after the treatment and the differences of the data between Group A and Group C had no obvious statistical significance (P > 0.05) in 7 days after the treatment. Conclusion The method of closed continuous irrigation and drainage is simple and practicable, and can reduce the pain of the patients and obviously promote the healing of infected incision, which is the recommendable method for treating postoperative incision infection.