海南黎族妇女宫颈人乳头瘤病毒感染现状及相关因素分析

Current situation of cervical HPV infection in Li nationality women of Hainan province and its related factors

摘要:

目的  探讨海南省黎族妇女宫颈人乳头瘤病毒（HPV）感染的分布情况及高危因素。方法  于2013年1月-2013年12月，采用导流杂交技术对海南省陵水县、昌江县的832例妇女进行21种HPV基因分型检测及流行病学问卷调查，并对与HPV感染相关的因素进行分析。结果  在被调查的832例妇女中，HPV感染患者为216例，总感染率为25.96％（216/832）。共检测出20种HPV亚型，HPV感染率排在前5位的亚型从高到低依次为HPV52（6.25％，52/832）、18（3.97％，33/832）、58（3.61％，30/832）、16（3.25％，27/832）和53（3.13％，26/
832）。HPV感染的高峰年龄为16～30岁。多因素Logistic回归分析结果表明，年龄（P =0.012）、妊娠次数（P =
0.002）、性伴侣数（P =0.028）和初次性生活年龄（P =0.038）为影响HPV感染的危险因素。结论  海南黎族妇女宫颈HPV感染率较高，主要为单一基因型感染，感染的高峰年龄为16～30岁，感染率最高的5个基因型依次为HPV52、18、58、16和53，年龄、初次性生活年龄、性伴侣数及妊娠次数是影响HPV感染的危险因素。

关键词:

 ;黎族;基因分型;宫颈病变;乳头状瘤病毒

Abstract:

Objective To explore the distribution and risk factors of cervical HPV infection in Li nationality women of Hainan province. Methods Epidemiological survey and 21 kinds of HPV genotype detection were carried out by hybridization technique in 832 women of Changjiang and Lingshui Li autonomous counties of Hainan province from January to December 2013. Factors associated with HPV infection were analyzed. Some of the women with positive HPV accepted TCT detection. Results Among the 832 women who were investigated, 216 women were found to have HPV infection and the total infection rate was 25.96% (216/832). There were totally 20 HPV genotypes. The genotypes of HPV infection rate ranked in the top five were HPV52 (6.25%, 52/832), 18 (3.97%, 33/832), 58 (3.61%, 30/832), 16 (3.25%, 27/832) and 53 (3.13%, 26/832). The peak age of HPV infection was 16-30 years. Multivariate logistic regression analysis showed that age (P = 0.012), number of pregnancy (P = 0.002), number of sexual partners (P = 0.028) and age of the first sexual life (P = 0.038) were the risk factors for HPV infection. Conclusions The rate of cervical HPV infection is high in Li women in Hainan province mainly with single genotype infection. The peak age of HPV infection is 16-30 years. The genotypes of HPV infection rank in the top five are HPV52, 18, 58, 16 and 53. Age, age of the first sexual life, number of sexual partners and pregnancy are the risk factors for HPV infection.

Key words:

Li nationality; genotyping; cervical lesion; human papillomavirus