黏结蛋白聚糖2及E-钙黏蛋白的表达及与结直肠腺癌淋巴结转移的关系

Relationship between syndecan 2 and E-cadherin expressions and lymphatic metastasis in colorectal adenocarcinoma

摘要:

目的  探讨黏结蛋白聚糖2（syndecan 2）和E-钙黏蛋白（E-cadherin）表达与结直肠腺癌侵袭、转移的关系。方法  应用免疫组织化学SP法检测75例结直肠腺癌中的syndecan 2和E-Cadherin的表达，45例腺瘤性息肉、30例正常结直肠做对照组，采用SPSS 16.0统计软件进行数据分析，计数资料进行χ2检验。结果  Syndecan 2在结直肠腺癌、腺瘤性息肉、正常结直肠组织中表达阳性率分别为43%、80%及100%，与腺癌淋巴结转移、肌层浸润深度呈正相关。E-Cadherin的表达阳性率分别为66%、85%和100%，与腺癌淋巴结转移、肌层浸润深度呈负相关。结论  Ayndecan 2和E-Cadherin在结直肠腺癌中表达减少，syndecan 2高表达、E-Cadherin低表达提示结直肠腺癌淋巴结转移发生率高。

Abstract:

Objective To investigate the relationship between the expressions of syndecan 2 and E-cadherin and lymphatic metastasis in colorectal adenocarcinoma. Methods The expressions of syndecan 2 and E-cadeherin were tested in 75 specimens of colorectal carcinoma, 45 adenomatous polyps and 30 normal mucosas using immunohistochemical method. Chi-square test was used to analyze data with SPSS 16.0 software. Results The positive expression rate of syndecan 2 was 43%, 80% and 100% in colorectal carcinomas, adenomatous polyps and normal mucosa, respectively. The expression of syndecan 2 was positively correlated with lymphatic metastasis and the depth of invasion into muscularis. The positive expression rate of E-cadherin was 66%, 85% and 100% in colorectal carcinomas, adenomatous polyps and normal mucosa, respectively. The expression rate of E-cadherin was negatively correlated with lymphatic metastasis and the depth of invasion into muscularis. Conclusions Syndecan 2 and E-cadherin expressions decrease in colorectal adenocarcinoma compared to normal mucosa. The high expression of syndecan 2 with low expression of E-cadherin is significantly correlated with lymphatic metastasis.