血液透析合并慢性乙型肝炎患者血清β2-微球蛋白水平及其影响因素

Level of serum beta2-microglobulin and its influencing factors in hemodialysis patients with chronic hepatitis B

摘要:

目的  观察血液透析合并慢性乙型肝炎（简称慢性乙肝）患者血清β2-微球蛋白（β2-MG）水平，并探讨血清β2-MG的影响因素。方法  按照“慢性乙型肝炎防治指南（2010年版）”筛选行血液透析治疗的慢性乙肝患者，30例纳入研究。选择30例乙肝病毒（HBV）阴性的血液透析患者作为对照组；用t检验比较两组实验室指标，用多元线性回归分析法分析影响血清β2-MG的因素。结果  HBV阳性组血清β2-MG水平为（65.64±10.18）μg/ml，较HBV阴性组（44.90±12.81）μg/ml显著升高（P <0.010）。多元线性回归分析显示，血清β2-MG水平与血清清蛋白呈负相关（B=-0.001，P =0.015），与HBV感染、透析龄及谷丙转氨酶呈正相关（B=14.127，P =0.000；B=0.421，P =0.001；B=0.077，P =0.032）。结论  血液透析合并慢性乙肝患者血清β2-MG水平较HBV阴性的血液透析患者显著升高，且与血清清蛋白、谷丙转氨酶、HBV感染及透析龄有关。

Abstract:

Objective To observe the level of serum beta2-microglobulin (β2-MG) in hemodialysis patients with chronic hepatitis B, and to discuss its influencing factors. Methods Referring to Guidelines for Chronic Hepatitis B in China (version 2010), 30 hemodialysis patients with chronic hepatitis B were included in this study. And 30 hemodialysis patients without hepatitis B virus (HBV) were selected as controls. Blood laboratory indexes were compared by t test. Factors influnecing serum β2-MG were analyzed with multiple linear regression analysis. Results The level of serum β2-MG in the HBV-positive group was (65.64 ± 10.18) μg/ml which was significantly higher than (44.90 ± 12.81) μg/ml in the HBV-negative group (P < 0.01). Multiple linear regression analyses showed that the level of serum β2-MG was negatively correlated to serum albumin (ALB) (B = -0.001, P = 0.015), and positively correlated to HBV infection, duration of dialysis and alanine aminotransferase (ALT) (B = 14.127, 0.421 and 0.077; P = 0.000, 0.001 and 0.032 respectively). Conclusions The level of serum β2-MG in hemodialysis patients with chronic hepatitis B is significantly high when compared with hemodialysis patients without HBV infection. And serum β2-MG is associated with serum ALB and ALT, HBV infection and duration of dialysis.