P-Akt在预测乳腺癌术后转移复发中的临床意义

Clinical significance of p-Akt in predicting metastasis of breast cancer after surgery

摘要:

目的  探讨p-Akt在预测乳腺癌术后转移复发中的临床意义。方法  选择该院2001年1月-2010年3月收治的乳腺癌术后261例患者为研究对象，将其分为术后转移复发组（114例）和术后未转移复发组（147例），采用免疫组织化学方法检测其p-Akt的表达，并分析p-Akt的异常表达与乳腺癌术后转移复发的相关性。结果  乳腺癌癌旁正常组织与乳腺癌组织间p-Akt的表达差异有统计学意义（P <0.05）；乳腺癌术后转移复发与未转移复发患者的乳腺癌组织p-Akt的表达比较差异有统计学意义（P <0.05）。p-Akt的异常表达与乳腺癌的肿瘤大小、淋巴结转移和TNM分期呈显著相关性（P <0.05）。单因素Logistic回归分析发现，p-Akt的异常表达与乳腺癌术后转移复发有显著的相关性（P =0.043，RR=1.638，95%Cl为1.337-1.955）。结论  p-Akt的异常表达与乳腺癌术后转移复发呈显著相关。

Abstract:

Objective To study the clinical significance of p-Akt in predicting the metastasis of breast cancer after surgery. Methods A total of 261 patients who were admitted into our hospital after breast cancer surgery from January 2001 to March 2010 were studied. There were 114 patients in metastasis group and 147 patients in non-metastasis group. The expression of p-Akt in the breast cancer patients with or without metastasis after surgery was detected by immunohistochemistry and the correlation between the expression of p-Akt and breast cancer metastasis was analyzed. Results There was significant difference in p-Akt expression between normal breast tissue and breast cancer tissues (P < 0.05). The p-Akt expression of breast cancer tissues also had significant difference between the metastasis group and non-metastasis group (P < 0.05). The abnormal p-Akt expression was significantly associated with the tumor size, regional lymph node metastasis and TNM staging of the patients with breast cancer (P < 0.05). Univariate logistic regression analysis showed that abnormal expression of p-Akt was correlated with the metastasis of breast cancer after surgery (P = 0.043, RR = 1.638, 95%Cl: 1.337-1.955). Conclusions The abnormal expression of p-Akt may be associated with the metastasis of breast cancer after surgery.