可溶性内皮细胞蛋白C受体和高敏C反应蛋白水平预测糖尿病患者血管并发症的价值

Role of sEPCR and hsCRP levels in prediction of vascular complications of patients with diabetes mellitus

摘要:

目的  探讨可溶性内皮细胞蛋白C受体（sEPCR）和高敏C反应蛋白（hsCRP）预测糖尿病（DM）患者血管并发症的价值。方法  20例1型DM患者、30例2型DM患者及30例健康志愿者纳入该次研究。酶联免疫吸附法（ELISA）来测定受试者血清sEPCR和hsCRP含量。结果  与对照组相比，两种类型糖尿病患者中sEPCR和hsCRP水平都升高。sEPCR能够预测1型糖尿病患者大血管并发症和血栓形成，P值分别为0.016和0.015。而hsCRP可以明显预测2型糖尿病患者的大血管并发症，P =0.042。结论  1型和2型糖尿病患者sEPCR和hsCRP水平高于健康志愿者，提示其血管内皮功能损伤。sEPCR对1型糖尿病患者大血管并发症和血栓形成有一定预测作用，而hsCRP对2型糖尿病患者大血管并发症有一定预测作用。

Abstract:

Objective To measure soluble endothelial protein C receptor (sEPCR) and high-sensitivity C reactive protein (hsCRP) levels as markers of endothelial damage in both types of diabetes mellitus  (DM) and to determine if they can be used as predictors of vascular complications.  Methods Fifty patients with DM (20 with type 1 and 30 with type 2 DM) and 30 healthy subjects were included. All were subjected to measurement of sEPCR and hsCRP by enzyme linked immunosorbent assay. Results sEPCR and hsCRP were significantly increased in both types of DM when compared to the control group. sEPCR was a significant predictor of macrovascular complications and thrombosis in type 1 DM (P = 0.016 and P = 0.015, respectively), while hsCRP was a significant predictor of macrovascular complications in type 2 DM (P = 0.042). Conclusions Patients with type 1 or type 2 DM exhibit higher sEPCR and hsCRP levels compared to healthy controls, which suggest endothelial damage. sEPCR could be used as a predictor of macrovascular complications and thrombosis in type 1 DM, whereas hsCRP might be used as a predictor of macrovascular complications in type 2 DM.