PI3K/Akt/mTOR信号通路在常见妇科疾病中的研究进展

Research progress of PI3K/Akt/mTOR signaling pathway functioning in common gynecological diseases

摘要:

磷脂酰肌醇3激酶/蛋白激酶B（PI3K-Akt）信号通路是细胞内重要信号转导通路，也是机体内一条重要的信号通路，在细胞生长、增殖、分化和蛋白合成等过程中起重要作用。子宫内膜癌、子宫内膜异位症、多囊卵巢综合征、卵巢癌等属于常见的女性生殖系统疾病，与机体内磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白（PI3K/Akt/mTOR）信号通路和雌激素水平异常存在一定的相关性。本文就PI3K/Akt/mTOR信号通路在常见妇科疾病中的作用作一综述，以期为常见妇科疾病靶向治疗提供新思路。

Abstract:

PI3K-Akt signaling pathway is an important intracellular signal transduction pathway. It plays an important role in the body which contributes to the cell growth, proliferation, differentiation and protein synthesis. Common gynecological diseases such as endometrial cancer, endometriosis, polycystic ovary syndrome and ovarian cancer have correlations with the PI3K/Akt/mTOR signal pathway and estrogen level. In this article, we reviewed the roles of PI3K/Akt/mTOR signal pathway in the common gynecological diseases, in order to look for a new target therapy for these diseases.