平肝益肾汤联合前列地尔治疗椎-基底动脉供血不足性眩晕疗效及对患者血清内皮素-1和降钙素基因相关肽水平的影响

Efficacy of Ping-gan-yi-shen decoction in combination with Alprostadil in treatment of vertebra-basilar artery ischemic vertigo and its effects on level of ET-1 and CGRP

摘要:

目的  探讨平肝益肾汤联合前列地尔治疗椎-基底动脉供血不足性眩晕的临床疗效及对患者血清内皮素-1（ET-1）和降钙素基因相关肽（CGRP）水平的影响。方法  选取河南中医学院第一附属医院就诊的120例椎-基底动脉供血不足性眩晕患者，并按照随机数字表法随机分为两组。对照组给予前列地尔治疗，观察组在对照组基础上联合应用平肝益肾汤治疗。评价比较组间临床疗效、椎-基底动脉血流速度及血清ET-1、CGRP水平。结果  疗效评价后观察组治疗总有效率明显高于对照组（96.7% vs 86.7%，P <0.05）。观察组治疗后与对照组比较，左侧椎动脉、右侧椎动脉及基底动脉血流速度增快[（33.7±4.5）cm/s vs （28.5±4.3）cm/s，（34.3±5.6）cm/s vs （29.2±5.1）cm/s，（36.9±6.7）cm/s vs （30.5±5.8）cm/s，P <0.05]，ET-1水平下降[（122.5±9.7）ng/L vs （142.3±10.6）ng/L，P <0.05]，CGRP水平升高[（32.2±3.8）ng/L vs （26.9±3.4）ng/L，P <0.05]。结论  平肝益肾汤联合前列地尔治疗椎-基底动脉供血不足性眩晕疗效可靠，能够显著提高临床疗效，改善椎-基底动脉供血，调节机体ET-1和CGRP水平，临床上值得应用。

Abstract:

Objective To investigate the efficacy of Ping-gan-yi-shen decoction in combination with Alprostadil in treatment of vertebra-basilar artery ischemic vertigo and its effects on level of endothelin-1 (ET-1) and calcitonin gene-related peptide (CGRP). Methods Patients of vertebra-basilar artery ischemic vertigo were divided into two groups equally. The control group was treated with Alprostadil, while the observation group was treated with Ping-gan-yi-shen decoction in combination with Alprostadil. Then, the curative efficacy, blood flow velocity of vertebra-basilar artery, serum ET-1 and CGRP were observed and compared. Results The total therapeutic efficacy ratio in the observation group was statistically higher than that in the control group (96.7% vs 86.7%, P < 0.05). After the treatment, in comparison with the control group, the observation group had statistically more increased blood flow velocity of left vertebral artery, right vertebral artery and basal artery [(33.7 ± 4.5) cm/s vs (28.5 ± 4.3) cm/s, (34.3 ± 5.6) cm/s vs (29.2 ± 5.1) cm/s, (36.9 ± 6.7) cm/s vs (30.5 ± 5.8) cm/s, P < 0.05]. And the observation group had statistically lower level of ET-1 [(122.5 ± 9.7) ng/L vs (142.3 ± 10.6) ng/L, P < 0.05] and higher level of CGRP [(32.2 ± 3.8) ng/L vs (26.9 ± 3.4) ng/L, P < 0.05] in comparison with the control group. Conclusions Ping-gan-yi-shen decoction in combination with Alprostadil is effective for vertebra-basilar artery ischemic vertigo, which can significantly increase curative efficacy, improve blood supply of vertebra-basilar artery and regulate level of ET-1 and CGRP.